Exploring molecular profiles in inflammatory skin diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot project aims to utilize a systems medicine approach to identify regulatory networks and their disruptions in psoriasis and atopic dermatitis. By integrating and modeling data across various cellular levels and time, the study will analyze the effects of licensed biologics during routine care on disease control. It involves ultra-deep phenotyping and molecular characterization of patients to generate insights into disease pathways and extract molecular signatures that correlate with clinical severity scores. The study will focus on differentially expressed genes and other molecular signatures associated with disease activity and progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to provide written informed consent and comply with the protocol
* Dermatologist-diagnosed chronic inflammatory skin disease
* Subject receives systemic therapy within routine care (in-label use of biologics)

Exclusion Criteria:

* Subject is unable to provide written informed consent or comply with the protocol.
* Having used immunosuppressive/immunomodulating therapy or phototherapy within 4 weeks before the baseline visit.
* Treatment of selected skin areas to be examined with topical corticosteroid or topical calcineurin inhibitor within 1 week before the baseline visit.

Where it's running

• Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel
  Kiel, Germany Recruiting

Study contacts

• Principal investigator: Stephan Weidinger, MD — Department of Dermatology, university Hospital Schleswig-Holstein, Campus Kiel
• Study coordinator: Stephan Weidinger, MD
• Email: sweidinger@dermatology.uni-kiel.de
• Phone: 004943150021101

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.