Exploring immune responses in diseases like psoriasis and eczema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the metabolic profiles associated with immune-mediated diseases, including primary immunodeficiency, psoriasis, and atopic dermatitis. Participants aged 18-75, including healthy volunteers, will undergo screening, medical history assessments, and physical exams. The study involves collecting skin biopsies, blood samples, and other biological materials to analyze how immune responses and skin healing are interconnected. The goal is to better understand the metabolic changes that occur in these conditions to inform future treatments.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Meets one of the following:

   1. Has documentation of PID confirmed by genetic evaluation demonstrating a deleterious variant in the gene (or genes) known to be associated with immune deficiency (confirmed PID); or
   2. Has documented variant of undetermined significance in a gene (or genes) that is predicted to be deleterious in immune function by the investigators OR a clinical history of infections which are more frequent, more chronic, or more severe than normal (suspected PID); or
   3. Has physician-diagnosed psoriasis; or
   4. Has physician-diagnosed AD; or
   5. Does not have clinically apparent evidence of any monogenic or digenic immune defect, AD, or psoriasis (healthy volunteers).
2. Aged 18 to 75 years.
3. Willing to allow storage of blood, biopsy tissue, bacterial and fungal cultures, and any other samples collected for future research.
4. Able to provide informed consent.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Current or prior (within 3 months) anticoagulant or anti-platelet therapy (other than aspirin or non-steroidal anti-inflammatory drugs).
2. Current or prior (within 3 months) use of immunomodulatory drugs (eg, chemotherapy, steroids), except if approved by the principal investigator.
3. History of keloid formation.
4. Pregnancy, lactating, or breastfeeding.
5. Any condition that, in the opinion of the investigator, contraindicates participation in the study.

Co-enrollment guidelines: Participants may be co-enrolled in other studies; however, study staff should be notified of co-enrollment.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Ian A Myles, M.D. — National Institute of Allergy and Infectious Diseases (NIAID)
• Study coordinator: Jodi L Blake, R.N.
• Email: jodi.blake@nih.gov
• Phone: (301) 605-2896

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PALLAS 311 nm UVB laser treatment for vitiligo, psoriasis, alopecia areata, and atopic dermatitis

  This study will test the PALLAS 311 nm UVB laser as an in-clinic, twice-weekly treatment for adults with vitiligo, psoriasis, alopecia areata, or atopic dermatitis for up to three months.

  Recruiting Szeged University · Szeged, Csongrád-Csanád Vármegye · NCT07250997

• New ceramide‑and‑coconut‑oil skin barrier cream versus petrolatum for dry or irritated skin

  This study will test whether a new ceramide- and coconut oil–based cream can improve skin hydration and reduce dryness and itch in adults with mild to moderate psoriasis, atopic dermatitis, contact dermatitis, or xerosis.

  Recruiting Makati Medical Center · Makati City, National Capital Region · NCT07183423

• Evaluating full-body imaging technology for skin disease detection

  This study is testing a new full-body imaging technology to see if it can help doctors better detect and monitor skin diseases like skin cancer and eczema.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06989216

• Biomarkers that predict how skin-disease treatments will work

  Researchers are testing blood and skin markers to see if they can forecast which patients with inflammatory skin diseases will respond to systemic treatments over a year.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06599411

• Understanding the factors influencing chronic inflammatory skin diseases

  This study is trying to understand what causes different types of chronic skin conditions, like eczema and psoriasis, to behave differently in patients over time.

  Recruiting University Hospital Schleswig-Holstein · Kiel · NCT05928169

• Understanding skin bacteria in patients with eczema and psoriasis

  This study is trying to see how skin bacteria affect people with eczema and psoriasis to better understand their skin health and treatment responses.

  Recruiting University of Rochester · Rochester, New York · NCT04170244

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.