Early vs. Late Upper Premolar Extraction and Front-Tooth Movement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two timing strategies for extracting the upper first premolars in patients aged 13 to 25 with Class I or Class II malocclusion. Participants will receive fixed orthodontic appliances and bilateral maxillary first premolar extractions, assigned to early extraction (before or within one week of appliance placement) or late extraction (after leveling and alignment but before space closure). Outcomes include the rate of space closure during en-masse anterior retraction, mesial movement of the first molars, gingival cleft formation, extraction ease and duration, and patient-reported pain and anxiety, with assessments at baseline, 3 months, and 6 months. Digital models will be used to quantify changes. The trial plans to enroll 26 participants to compare the two timing strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 13-25 years
2. No prior orthodontic treatment
3. Overjet 4-8 mm
4. Symmetric dental arches with mild to moderate crowding requiring bilateral first premolar extractions.
5. Probing depth less than 4 mm on all teeth

Exclusion Criteria:

1. History of dental trauma
2. Poor oral hygiene
3. Syndromic patients
4. Systemic diseases or medications affecting bone metabolism

Where it's running

• Shifa College Of Dentistry
  Islamabad, Pakistan Recruiting

Study contacts

• Study coordinator: Shanzay Khan, BDS, Post Graduate Resident
• Email: shanzaykhan1997@gmail.com
• Phone: 03245555716

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.