Do TPU or PETG clear aligners feel different for teens and young adults?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, parallel-group trial compares patient-reported outcomes for clear aligners made from two thermoplastic materials (TPU vs PETG) in mild-to-moderate malocclusion requiring non-extraction treatment. Eligible participants aged 15–30 with full permanent dentition (first molar to first molar) and crowding under 8 mm are randomly assigned to receive either TPU- or PETG-made aligners. Aligners are worn in 10-day intervals with controlled incremental tooth movements, and patient-reported outcomes are collected at five predefined time points, starting before wear and continuing after insertion. Outcomes include pain, mucosal trauma, tooth sensitivity, tooth mobility, and potential material-related allergic symptoms, with assessors and participants blinded to material. The trial is conducted at CMH Lahore Medical College and Institute of Dentistry in Pakistan, with independent randomization and allocation concealment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Patient aged between 15 and 30 years.

  * Permanent dentition, with all permanent teeth from first molar to first molar present.
  * Mild to moderate crowding less than 8 mm.
  * Non-extraction orthodontic treatment plan.
  * Ability and willingness to wear aligners for the required time.
  * Willingness to attend regular visits during orthodontic treatment.

Exclusion Criteria:

* • Syndromic patients.

  * Known allergy to thermoplastic materials.
  * Patients with systemic diseases that may affect orthodontic treatment or outcome assessment.
  * Patients requiring extraction as part of orthodontic treatment.

Where it's running

• CMH Lahore Medical college and institue of dentistry
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Principal investigator: Haris Khan, Bds,fcps — CMH Lahore medical college and IOD
• Study coordinator: Haris Khan, Bds, Fcps
• Email: drhariskhan@gmail.com
• Phone: +923336159951

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.