Cognitive Behavioral Therapy for Insomnia in Brain Tumor Patients

Cognitive Behavioral Therapy for Insomnia in Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial

PHASE2 · Virginia Commonwealth University · NCT06439420

This study is testing if Cognitive Behavioral Therapy for Insomnia can help people with brain tumors who have trouble sleeping feel better and improve their overall wellbeing.

Quick facts

PhasePHASE2
Study typeInterventional
Enrollment60 (estimated)
Ages18 Years and up
SexAll
SponsorVirginia Commonwealth University (other)
Drugs / interventionsradiation
Locations1 site (Richmond, Virginia)
Trial IDNCT06439420 on ClinicalTrials.gov

What this trial studies

This study investigates the feasibility and acceptability of using Cognitive Behavioral Therapy for Insomnia (CBT-I) in patients with primary brain tumors who also suffer from insomnia. It aims to evaluate recruitment, enrollment, data collection, and retention processes for this behavioral health intervention. The long-term goal is to expand treatment options for neuro-oncology patients and enhance their overall wellbeing and mission readiness.

Who should consider this trial

Good fit: Ideal candidates include individuals diagnosed with primary brain tumors who are experiencing insomnia and meet specific eligibility criteria.

Not a fit: Patients with major communication difficulties or those unable to participate in virtual meetings may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve sleep quality and overall quality of life for patients with primary brain tumors.

How similar studies have performed: While there is limited research specifically targeting this population, similar approaches using CBT-I have shown promise in other patient groups with insomnia.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Primary brain tumor diagnosis (grade I-IV)
* \>/=2weeks post-cranial resection (if applicable)
* \>/=1 month post-radiation therapy (if applicable)
* Able to understand, speak, and read English
* Absence of major cognitive concerns
* Meet Diagnostic and statistical manual of mental disorders version 5 (DSM-V) diagnostic criteria for insomnia
* Reliable internet connection

Exclusion Criteria:

* Major communication difficulties that would prohibit effective intervention
* Inability to attend weekly virtual group meetings
* Inability to understand and provide informed consent
* Currently a prisoner or residing in a correctional facility

Where this trial is running

Richmond, Virginia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Primary Brain Tumor, Glioblastoma, Astrocytoma, Oligodendroglioma, Meningioma, Primary Central Nervous System Lymphoma, Brain Tumor, Insomnia

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.