Bupivacaine Liposomes vs. Bupivacaine for pain relief after laparoscopic hepatobiliary pancreatic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized phase 4 study, adults undergoing laparoscopic hepatobiliary pancreatic surgery receive an ultrasound-guided costal margin block with either bupivacaine liposomes plus standard bupivacaine or standard bupivacaine alone. All participants follow a standardized anesthesia and postoperative analgesia protocol, with pain monitored via the visual analog scale and managed with an opioid-sparing regimen as needed. The primary aim is to determine if the liposomal formulation extends analgesia and reduces opioid requirements compared with conventional bupivacaine. Safety data, including adverse events related to nerve blocks and local anesthetics, are collected throughout the postoperative period. The study uses a complete randomization scheme and compares outcomes between the two groups."

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-80 years old ASA Level I-III Laparoscopic Hepatobiliary Pancreatic Surgery

Exclusion Criteria:

* Body Mass Index (BMI) ≥ 30 kg/m ² or ≤ 15 kg/m ² Known alcohol or drug abuse History of upper abdominal surgery Congenital coagulation dysfunction Localized or systemic infection Peripheral neuropathy Unable to understand the research plan

Where it's running

• Tongji Hospital
  Wuhan, Hubei, China Recruiting
• Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. 1095 Jiefang Avenue, Wuhan City, Hubei Province
  Wuhan, Hubei, China Not yet recruiting

Study contacts

• Principal investigator: Wei Mei, MD — Tongji Medical College, Huazhong University of Science and Technology
• Study coordinator: Li Xu, MD
• Email: 65022661@qq.com
• Phone: 86-13277070358

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.