Adding dexmedetomidine to spinal bupivacaine for pain relief during knee surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares three intrathecal doses of dexmedetomidine (4, 8, and 12 μg) given with hyperbaric bupivacaine for patients undergoing knee orthopedic surgery. The primary outcome is duration of analgesia and the secondary outcome is the profile of adverse effects. Male adults aged 18–65 with ASA physical status I–II are eligible and receive a single spinal anesthetic with the assigned adjunct dose. The study is conducted at a single center (Cairo University) and monitors postoperative pain duration and safety measures without increasing the local anesthetic dose.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 65 years.
* American Society of Anesthesiologists (ASA) physical status I-II.
* Male patients scheduled for knee orthopedic surgery.

Exclusion Criteria:

* Patients with psychiatric disorders.
* History of drug addiction.
* Contraindication for regional anesthesia.
* History of hypersensitivity to the study drugs.
* Previous administration of opioids and/or other central nervous system depressants during current hospital admission.

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed A Ismail, MSc
• Email: ahmed.ali39348@postgrad.kasralainy.edu.eg
• Phone: 00201115746779

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.