Sponsor or institution
Clinical trials and research at Van Andel Research Institute
As of November 12, 2026, Find a Trial lists 1 clinical trial run by Van Andel Research Institute that is recruiting, in United States. 1 was first registered in the last 30 days. There are also 101 NIH-funded research projects at this institution, with $63.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1Clinical trials
- 101NIH research projects
- 1New in 30 days
- 1Country
All recruiting trials (1)
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Understanding immune clues to depression in perimenopause
This study tests whether immune and epigenetic changes during perimenopause help explain why some women develop depression.
NIH-funded research (newest 40 of 101)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Histone mutations in cancer pathogenesis
A cancer-focused study looks at how changes in histone genes found in patients may drive tumor growth and interact with other cancer mutations.
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circSATB2: a new regulator in arsenic-related cancer
A new gene-related mechanism linked to arsenic exposure and cancer is being studied to understand how a circular RNA from SATB2 may influence cancer development.
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Bacteria that influence insulin signaling and Type 2 diabetes
Researchers will study gut bacteria that may change how insulin works in the body, with a focus on diabetes risk.
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Understanding how amyloid plaques form in Alzheimer's disease
A research project will look at how misfolded amyloid proteins build up in the brains of people and mouse models with Alzheimer’s disease to uncover new clues for diagnosis and treatment.
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How DNA methylation patterns are kept in colon cancer and what happens when they’re disrupted
Researchers are studying how the molecular marks that control gene activity are maintained in colon cancer and how breaking these marks affects cancer growth and treatment response.
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ER quality control across cell types with unique ER shapes
A scientist will study how the endoplasmic reticulum keeps cells healthy by managing its structure and stress responses in different cell types, including neurons.
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AHR's role in shaping bladder cancer response to immunotherapy
This project looks at how the AHR pathway affects how bladder cancer patients respond to immune checkpoint therapies and the risk of serious treatment-related side effects.
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Understanding abnormal DNA methylation in cancer for better diagnosis and treatment
Researchers are building tools and skills to study how chemical marks on DNA influence cancer, with the goal of improving how we understand and treat the disease.
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Understanding how cancer gene switches go wrong and drive tumor behavior
This grant supports research to understand how epigenetic changes influence cancer development and treatment resistance in patients.
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Single-cell and single-molecule profiling of how chromatin proteins control immune responses
Scientists are developing a new way to map how specific chromatin proteins and DNA marks regulate immune cells, with the goal of better cancer control and safer autoimmunity.
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Understanding beta-cell subtypes in type 2 diabetes
This grant aims to understand different beta-cell subtypes in type 2 diabetes to identify how they contribute to blood sugar control and disease progression.
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Molecular mechanisms of protein glycosylation and trafficking
A study to understand how proteins get sugar modifications and are moved inside cells, which could help explain certain disease processes.
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Molecular basis of how microtubules and intermediate filaments work together in brain cells
Scientists are studying how tiny cellular scaffolds interact in myelinated brain fibers to better understand nerve cell structure and function.
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Fatty acid metabolism problems in mitochondrial disease models
This NIH grant supports studying how fat metabolism in mitochondria goes wrong in disease models, with the hope of helping kids with mitochondrial disorders.
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Structural mechanism of DNA replication in cancer-related research
A groundbreaking grant studies how the basic machinery that copies DNA works, with potential implications for understanding and treating cancer.
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Developmental changes in autism risk linked to mom’s metabolism and genes
A study using fruit flies and mice will explore how a mother’s metabolic state may influence the child’s brain development and autism-related features.
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Targeting CD4 T cell metabolism to treat CNS autoimmune disease
Aims to see if changing methionine metabolism in immune cells can slow or stop CNS autoimmune disease, like MS, by weakening harmful T cells while protecting good immune responses.
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Epigenetic silencing of retrotransposons in cancer
This NIH grant aims to understand how cells keep retrotransposons quiet at the genetic level to protect healthy cells from damage and inflammation in cancer.
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Understanding how DNA methylation changes drive colon cancer and how we might fix them
A study to uncover how epigenetic marks that control gene activity go wrong in colon cancer and explore ways to target these changes for better treatment.
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Understanding how DNA methylation works in cancer cells
Researchers are studying how a key DNA-modifying enzyme, DNMT3A, works inside living cancer and normal cells to influence brain development, body size, and blood cell formation.
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Sex-specific bone mass regulation by the X-linked gene KDM5C
A researcher team is studying how the X-linked enzyme KDM5C influences bone mass in women, aiming to understand why osteoporosis risk differs by sex and how this pathway could be targeted in the future.
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Mysterious lysosome zip codes: unlocking how a key enzyme guides normal cellular trash disposal
A research project is studying the human enzyme that tags lysosomal proteins so they reach the right cell compartments, a process that can go wrong in autism-related conditions.
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Histotripsy ultrasound to boost the body’s attack on cancer
A new treatment uses focused ultrasound to break apart cancer cells non-invasively and trigger the immune system to fight cancer more effectively, including distant tumors.
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AHR's effect on immunotherapy response and side effects in bladder cancer
This project will look at whether AHR pathway activity in bladder tumors affects how people respond to immune checkpoint treatments and whether it triggers dangerous rapid tumor growth.
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Why some brain cells and networks are more vulnerable to harmful protein buildup
This project looks at how proteins linked to Alzheimer’s and related dementias, like tau and alpha‑synuclein, spread through connected brain cells and networks.
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Molecular switches in chromatin that drive cancer biology
A scientist is studying how chemical marks on DNA and histones control how genes are turned on or off in cancer, with the goal of finding new ways to treat disease.
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DNA methylation changes in Hutchinson-Gilford Progeria Syndrome
This project looks at how DNA methylation changes in people (and model systems) with Progeria to understand why aging happens so quickly.
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Viral-like DNA elements and joint aging in osteoarthritis
This project looks at whether viral-like DNA inside joint cells causes those cells to age and contribute to osteoarthritis in adults.
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How dietary fats change tumor growth and treatment response
This project looks at how the types of fats people eat change tumor behavior and whether those changes help people with cancer respond better to treatments.
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Mitochondrial fatty acid synthesis and how it controls energy and metabolism
This NIH grant explores how mitochondria manufacture fatty acids and how that process helps control the cell’s energy production and metabolism, which could shed light on diseases linked to mitochondrial function.
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Calorie reduction to help the immune system fight cancer
This project looks at whether eating fewer calories and increasing ketone availability helps immune T cells better fight tumors in people with cancer.
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How arsenic alters DNA packaging through small changes in H2B histone
This project looks at whether tiny changes in a DNA-packaging protein called H2B caused by arsenic exposure help drive cancers in people exposed to contaminated water.
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Immune changes linked to depression during perimenopause
This project looks at how hormone-related immune changes may cause depression in women going through perimenopause.
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Development and improvement of DNAm and RNA sequencing analysis tools for cancer research
A software grant to build and share tools that help scientists study DNA methylation and single-cell RNA data to understand how cancer starts and progresses.
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Tracing how past exposures leave mutational fingerprints in cancer DNA
This project aims to find the environmental or chemical causes behind the unique DNA mutation patterns seen in different cancers so people with cancer can learn what may have led to their tumor.
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How neurofibromin affects gene regulation related to estrogen receptors
This study is looking at how a protein called neurofibromin affects the way certain genes related to estrogen work, which could help us find new treatments for conditions linked to estrogen, especially for those with neurofibromatosis.
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Understanding what makes children susceptible to acute myeloid leukemia
This study is looking into why some children are more likely to get acute myeloid leukemia (AML) by exploring things like genetics and the environment, and it’s for families affected by this type of cancer to help find better ways to prevent and treat it.
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How NAIP proteins spot bacteria and trigger inflammation
Researchers are mapping how NAIP proteins recognize bacterial parts and turn on inflammatory responses to improve understanding of infections and inflammation.
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How the circular RNA circSATB2 may drive cancers caused by arsenic exposure
Researchers are looking at whether a circular RNA called circSATB2 and the small peptide it makes change gene control and contribute to cancers in people exposed to inorganic arsenic.
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Hidden biological switches that change a person's disease risk
Researchers are looking for internal molecular switches that make disease risk vary between people so care can be more tailored to each person.
Quick answers
How many clinical trials run by Van Andel Research Institute are recruiting right now?
1, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.