Molecular mechanisms of protein glycosylation and trafficking
Funded at Van Andel Research Institute · NIH-11394281 · Data updated 2026-11-12
A study to understand how proteins get sugar modifications and are moved inside cells, which could help explain certain disease processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | June 18, 2018 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $475,000 |
| NIH project number | 5R01CA231466-09 |
| Project ID | NIH-11394281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant; this is a basic science study.
✕Less likely to help
No direct patient involvement or benefit expected from participation in this project.
What this research studies
This project aims to uncover the detailed steps by which proteins receive sugar tags and are transported to their proper cellular locations. Researchers will examine structures of key enzymes and protein complexes involved in glycosylation and vesicle formation to map how these processes work together in cells. The findings could reveal targets for therapies in conditions where protein processing goes wrong. The work builds on prior discoveries about membrane protein complexes and lipid flipping that drive vesicle budding and trafficking.
Why it matters
Potential benefit: Better understanding of protein processing could lead to new approaches for treating diseases linked to glycosylation and trafficking defects.
How similar studies have gone: Previous work has successfully mapped structures of related enzymes and flippases, supporting further mechanistic insights.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Li, Huilin — Van Andel Research Institute
- Study coordinator: Li, Huilin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.