ER quality control across cell types with unique ER shapes
Official title: Regulation of Endoplasmic Reticulum (ER) Quality Control Across Cell types with Unique ER morphologies.
Funded at Van Andel Research Institute · NIH-11428039 · Data updated 2026-11-12
A scientist will study how the endoplasmic reticulum keeps cells healthy by managing its structure and stress responses in different cell types, including neurons.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | July 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $528,000 |
| NIH project number | 1R35GM165630-01 |
| Project ID | NIH-11428039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant as described; focus is on cellular and molecular mechanisms.
✕Less likely to help
No direct patient participation is described in this grant.
What this research studies
This project looks at how the ER changes its shape to support different cell functions and how it keeps proteins and lipids balanced. The research will explore how ER autophagy and related pathways influence ER health in various cells, including nerve cells. Findings could help us understand diseases where ER function is disrupted and point to new strategies to protect cells. The work combines cell biology approaches to map ER structure, signaling, and quality control across cell types.
Why it matters
Potential benefit: Understanding ER quality control could lead to therapies that preserve cellular health in diseases where ER function is compromised.
How similar studies have gone: Previous work shows ER-phagy and autophagy influence ER structure during cell differentiation, suggesting the approach is plausible.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Hoyer, Melissa J. — Van Andel Research Institute
- Study coordinator: Hoyer, Melissa J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.