How neurofibromin affects gene regulation related to estrogen receptors
Official title: Impact of neurofibromin on ER-alpha and nuclear speck post-transcriptional gene regulation
Funded at Van Andel Research Institute · NIH-11229089 · Data updated 2026-11-12
This study is looking at how a protein called neurofibromin affects the way certain genes related to estrogen work, which could help us find new treatments for conditions linked to estrogen, especially for those with neurofibromatosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $3,000 |
| NIH project number | 3F99CA284282-02S1 |
| Project ID | NIH-11229089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurofibromatosis type 1 or those affected by conditions related to estrogen receptor signaling.
✕Less likely to help
Patients without neurofibromatosis or unrelated estrogen receptor conditions may not receive any benefit from this research.
What this research studies
This research investigates the role of neurofibromin in regulating gene expression related to estrogen receptors, specifically focusing on ER-alpha. The study aims to understand how neurofibromin influences post-transcriptional gene regulation, which could have implications for conditions linked to estrogen signaling. By examining these mechanisms, the research seeks to uncover potential pathways that could be targeted for therapeutic interventions. Patients may benefit from insights gained regarding neurofibromatosis and estrogen-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions associated with neurofibromatosis and estrogen receptor dysregulation.
How similar studies have gone: While the specific focus on neurofibromin and ER-alpha is novel, related research on estrogen receptors has shown promising results in understanding their role in various conditions.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Dischinger, Patrick — Van Andel Research Institute
- Study coordinator: Dischinger, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.