DNA methylation changes in Hutchinson-Gilford Progeria Syndrome
Official title: Accelerated DNA Methylation Alterations in Hutchinson-Gilford Progeria Syndrome
Funded at Van Andel Research Institute · NIH-11326248 · Data updated 2026-11-12
This project looks at how DNA methylation changes in people (and model systems) with Progeria to understand why aging happens so quickly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $783,592 |
| NIH project number | 5R01AG084743-04 |
| Project ID | NIH-11326248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Hutchinson-Gilford Progeria Syndrome or cells derived from these patients, plus relevant model systems.
✕Less likely to help
The study may not benefit individuals without Progeria or those not participating in cell-based experiments.
What this research studies
Researchers will study how patterns of DNA methylation shift over time in cells from people with Progeria and in model systems. They will map methylation changes at high resolution during cell culture and aging, and test whether adjusting these patterns can extend the lifespan of Progeria models. The work builds on a recently developed mitotic clock called RepliTali to track cellular history and aging. The goal is to see if manipulating methylation can slow some aging processes in Progeria. This could point to new therapeutic strategies targeting epigenetic mechanisms.
Why it matters
Potential benefit: If successful, the work could reveal epigenetic targets to slow aging-like deterioration in Progeria.
How similar studies have gone: Previous studies suggest DNA methylation changes are linked to aging, with potential for epigenetic interventions, but this approach is novel for Progeria.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Laird, Peter W — Van Andel Research Institute
- Study coordinator: Laird, Peter W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.