Sponsor or institution
Clinical trials and research at University of New England
As of November 12, 2026, Find a Trial lists 41 NIH-funded research projects at this institution, with $16.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 41NIH research projects
NIH-funded research (newest 40 of 41)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Engineered protein materials to study wound healing and blood vessels
A researcher team at the University of New England is studying how the environment around a protein changes its behavior to better understand wound healing and blood vessel formation.
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Central and Peripheral Mechanisms of Corneal Pain
This NIH grant explores how corneal pain arises and is processed, with the goal of better understanding and one day reducing corneal pain for patients.
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HIV Tat and nerve pain in people with HIV: how immune pathways may drive HIV-related neuropathy
A patient-facing look at a grant studying how a protein from HIV (Tat) may trigger nerve pain in people with HIV through immune pathways, with findings that could lead to new treatments.
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How disrupting sensory nerve signals affects tibial bone density
This NIH grant studies how cutting signals from sensory nerves near the shin bone may change bone mass to help prevent fractures.
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Understanding why sex differences affect advanced knee osteoarthritis pain
Researchers are studying why men and women experience osteoarthritis pain differently, focusing on how pain changes from mid-stage to advanced stages and how biology in nerves may drive these differences.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
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Armadillo/b-Catenin mechanisms in fruit-fly pain signaling
Researchers will study how a gene similar to human beta-catenin in fruit flies affects how they feel and respond to painful stimuli.
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CaMPARI tool to map eye nerve cells and their function
A feasibility project to use CaMPARI3, a brain-mapping tool, to link how corneal nerve cells respond to stimuli with their molecular identities in people at UNE.
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Role of a brain region in epileptic seizures and SUDEP risk
A study in preclinical models explores how a specific brain area called the VMH may drive seizure spread and potentially SUDEP, which could lead to new targets to prevent severe seizures.
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Pesticide exposure, brain inflammation, and Parkinson-like damage in aging
This research tests whether pesticide exposure triggers brain inflammation that leads to Parkinson-like nerve cell damage in aging people and those with past pesticide contact.
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Proteins that control pain signals in sensory nerves
This work looks at whether increasing a natural protein in adult sensory nerve cells can lower persistent or chronic pain.
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How irisin affects bone health during exercise
This study is looking at how a substance called irisin, which is released from your muscles when you exercise, might help keep your bones strong and healthy, especially for older adults, and it will involve some patients trying out irisin infusions and exercise to see how it affects their bone health.
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How mitochondria control pain-sensing nerves
This project looks at how the tiny energy factories inside pain-sensing nerves change after injury and whether changing them can reduce long-lasting pain for people with chronic pain.
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How stress can make muscle pain last longer
This work explores how stress might cause short-term muscle pain to become long-lasting by changing support cells around nerves.
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How Tuberous Sclerosis tumors use tryptophan to grow
This project looks at whether blocking the breakdown of the amino acid tryptophan can slow growth of tumors in people with tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM).
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Building stronger bones by targeting a bone-cell protein (DOCK7)
This project tests whether targeting a protein called DOCK7 can help bone-forming cells make stronger bone for people with osteoporosis.
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Boosting blood vessel growth to help chronic wounds heal
Developing regenerative approaches that improve blood flow and control inflammation so people with slow-healing wounds—especially older adults and those with diabetes or obesity—can heal better.
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Nerve causes of pain in the front of the eye
This project maps the types of cornea nerves and brain circuits that drive ongoing eye pain for people with corneal pain.
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Understanding Nerves and Tibia Bone Strength
This research explores how sensory nerves in the leg affect the strength of your shin bone, aiming to prevent fractures.
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HIV protein Tat and nerve pain linked to immune sensors (Toll-like receptors)
This work tests whether the HIV protein Tat causes painful nerve damage by activating immune sensors called toll-like receptors in people with HIV who have sensory neuropathy.
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Understanding why advanced arthritis pain affects men and women differently
This research explores why advanced arthritis pain, which is often persistent and hard to treat, affects women more frequently and severely than men.
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Understanding sex differences in brain development after early life trauma
This project explores how early life stress, such as experiences in a neonatal intensive care unit, affects brain development differently in males and females, potentially leading to mood problems or chronic pain.
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How immune cells in women might protect against nerve pain from chemotherapy
This project explores how certain immune cells in female bodies may naturally reduce nerve pain caused by chemotherapy, aiming to find new ways to prevent this side effect.
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Investigating how a specific brain region affects epilepsy development
This study is looking at how a part of the brain called the ventromedial nucleus of the hypothalamus might influence epilepsy and the risk of sudden death in people with the condition, with the hope of finding new ways to prevent seizures and keep you safe.
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Investigating how RNA-protein interactions affect pain signaling
This study is looking at how certain proteins in our nerve cells affect pain signals, with the hope of finding new ways to help people manage chronic pain better.
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How mitochondria affect pain sensitivity and chronic pain development
This study is looking at how tiny parts of our cells called mitochondria affect pain-sensing nerves and how this might help us understand why some people develop long-lasting pain after an injury, with the hope of finding better ways to treat pain.
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Investigating how stress affects the transition from acute to chronic muscle pain
This study is looking at how stress might turn short-term muscle pain into long-lasting pain, using a special mouse model to see how stress affects pain signals, which could help us understand how managing stress might help people with chronic muscle pain.
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Investigating how nutrient uptake affects tumor growth in Tuberous Sclerosis Complex
This study is looking at how certain gene changes in people with Tuberous Sclerosis Complex (TSC) can lead to more nutrient absorption in cells, which might help tumors grow, and it aims to find ways to slow down this process to help manage tumors better for those living with TSC.
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Investigating new therapies for osteoporosis to improve bone health in aging patients
This study is looking for new ways to help older adults with osteoporosis by finding better treatments that can strengthen their bones and reduce the risk of fractures.
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Improving wound healing for patients with chronic conditions
This study is looking at new ways to help people heal better from wounds, especially those who might struggle with healing due to age, diabetes, or being overweight, by using special techniques like stem cells and growth factors to boost the body's natural healing process.
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Understanding how cells communicate and function in aging and stress.
This study is exploring how aging, stress, and metabolism affect our cells, and it's designed for researchers who want to learn more about how cells work together and respond to different conditions.
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Building research infrastructure and supporting investigator development
This study is all about helping researchers at the University of New England grow in their careers and work better together by providing support, guidance, and resources to make their research projects successful.
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Understanding how cell signaling affects health and disease
This study is looking at how different parts of our body, like the nervous and immune systems, work together and what goes wrong in diseases like chronic pain and neurodegenerative conditions, with the hope of finding new ways to improve health and treatment options for patients.
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Investigating the role of a protein in HIV-related nerve pain
This study is looking at how a specific protein from the HIV virus might cause nerve pain in people with HIV, and it's for anyone who has experienced this painful condition, as the researchers hope to find better ways to help manage it.
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Understanding pain mechanisms in the cornea
This study is looking at how pain from the eye's surface is felt and can sometimes lead to ongoing pain, and it's for anyone who experiences eye pain or wants to understand more about it.
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Understanding how certain immune cells help reduce pain in women undergoing chemotherapy
This study is looking at how certain immune cells might help reduce pain from chemotherapy in women, and it aims to find out how these cells work with nerve cells and are affected by hormones, so we can improve pain relief for women during cancer treatment.
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Understanding how sensory nerve disruption affects bone mass in the tibia
This study is looking at how nerves in your leg affect bone health, especially in the shin bone, to see if problems with these nerves can lead to weaker bones and more fractures, which could help find better ways to prevent and treat tibial fractures for patients like you.
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Understanding how early life trauma affects emotional and pain responses differently in males and females
This study looks at how early medical treatments, like those given to newborns in intensive care, can affect feelings and sensitivity to pain later in life, using young rats to explore the differences between males and females.
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Understanding why women experience more severe osteoarthritis pain than men
This study looks at why women with osteoarthritis often feel more pain than men by examining changes in nerves in mice, hoping to find new ways to help manage pain for everyone.
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How stress affects muscle pain through immune system interactions
This study is looking at how long-term stress might cause muscle pain by affecting the immune system, and it's designed for people who experience chronic pain related to stress, with hopes of finding new ways to help them feel better.
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