Investigating how a specific brain region affects epilepsy development
Official title: The Role of the Ventromedial Nucleus of the Hypothalamus in Epileptogenesis
Funded at University of New England · NIH-11098617 · Data updated 2026-11-12
This study is looking at how a part of the brain called the ventromedial nucleus of the hypothalamus might influence epilepsy and the risk of sudden death in people with the condition, with the hope of finding new ways to prevent seizures and keep you safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New England NIH-funded |
| Lab location | 1 site (Biddeford, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $142,000 |
| NIH project number | 5R16NS140309-02 |
| Project ID | NIH-11098617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy, particularly those at risk for SUDEP.
✕Less likely to help
Patients without epilepsy or those whose seizures are well-controlled may not benefit from this research.
What this research studies
This research explores the role of the ventromedial nucleus of the hypothalamus (VMH) in the development of epilepsy. By using preclinical models, the study aims to understand how changes in brain plasticity contribute to seizure propagation and the risk of Sudden Unexplained Death in Epilepsy (SUDEP). The researchers will analyze specific pathways and mechanisms that could potentially block seizure discharge from affecting critical brainstem areas responsible for vital functions. This approach may lead to new strategies for preventing seizures and their severe consequences.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of epilepsy and reduce the risk of SUDEP.
How similar studies have gone: While the specific focus on the VMH in relation to SUDEP is novel, similar research has shown promise in understanding seizure mechanisms and prevention strategies.
Where this research is happening
-
University of New England
Biddeford, United States Active
Researchers
- Principal investigator: Ferland, Russell James — University of New England
- Study coordinator: Ferland, Russell James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.