Investigating how nutrient uptake affects tumor growth in Tuberous Sclerosis Complex
Project 3 - Filippakis
This study is looking at how certain gene changes in people with Tuberous Sclerosis Complex (TSC) can lead to more nutrient absorption in cells, which might help tumors grow, and it aims to find ways to slow down this process to help manage tumors better for those living with TSC.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New England NIH-funded |
| Lab location | 1 site (Biddeford, United States) |
| Project ID | NIH-11005039 on NIH RePORTER |
What this research studies
This research focuses on Tuberous Sclerosis Complex (TSC), a genetic condition that leads to tumor growth in various organs. It examines how mutations in specific genes cause an increase in a cellular process called macropinocytosis, which helps cells absorb nutrients. The study aims to understand the role of tryptophan metabolism in this nutrient uptake and how inhibiting this process may reduce tumor growth in patients with TSC. By exploring these mechanisms, the research seeks to identify potential therapeutic targets for better management of TSC-related tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Tuberous Sclerosis Complex or related conditions.
Not a fit: Patients without Tuberous Sclerosis Complex or those with unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent tumor growth in patients with Tuberous Sclerosis Complex.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in tumor growth, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Biddeford, United States
- University of New England — Biddeford, United States (Active)
Researchers
- Principal investigator: Filippakis, Charilaos — University of New England
- Study coordinator: Filippakis, Charilaos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.