Understanding how sensory nerve disruption affects bone mass in the tibia
Official title: The Impact of Disrupting Sensory Innervation on Tibial Bone Mass
Funded at University of New England · NIH-10895590 · Data updated 2026-11-12
This study is looking at how nerves in your leg affect bone health, especially in the shin bone, to see if problems with these nerves can lead to weaker bones and more fractures, which could help find better ways to prevent and treat tibial fractures for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New England NIH-funded |
| Lab location | 1 site (Biddeford, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $177,500 |
| NIH project number | 5R16GM150784-02 |
| Project ID | NIH-10895590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for osteoporosis or those with a history of tibial fractures.
✕Less likely to help
Patients with healthy bone density and no history of fractures are unlikely to benefit from this research.
What this research studies
This research investigates the role of sensory nerves in maintaining bone health, specifically focusing on the tibia. It aims to understand how disrupting these nerves impacts bone mineral density and the risk of fractures. By studying the saphenous nerve and its communication with bone cells, the research seeks to identify factors that contribute to low bone density and increased fracture risk. Patients may benefit from insights that could lead to better prevention and treatment strategies for tibial fractures.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing tibial fractures in individuals with low bone mineral density.
How similar studies have gone: Other research has shown promising results in understanding the relationship between sensory nerves and bone health, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of New England
Biddeford, United States Active
Researchers
- Principal investigator: Becker, Kathleen a — University of New England
- Study coordinator: Becker, Kathleen a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.