Sponsor or institution

Clinical trials and research at The Netherlands Cancer Institute

• 46Clinical trials
• 2Countries

Newest trials

All recruiting trials (46)

• Omitting re-excision after complete primary melanoma excision

  This trial tests whether people with pT1b–pT4b cutaneous melanoma whose tumors were completely removed can safely skip the usual re-excision surgery.

  Recruiting at 10 sites Phase 3 The Netherlands Cancer Institute · 's-Hertogenbosch and 20 other locations · NCT07530887

• Living long-term with advanced GIST on tyrosine kinase inhibitors

  This observational project will collect medical records and patient questionnaires to see how long-term tyrosine kinase inhibitor treatment affects quality of life and survivorship for adults with advanced or metastatic GIST who have taken TKIs for at least two years.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07522762

• Ga68-PSMA PET/CT to tell radiation damage from tumor growth in brain metastases

  This project will test whether a Ga68-PSMA PET/CT scan can tell radiation necrosis apart from tumor regrowth in adults with brain metastases from lung cancer, melanoma, or breast cancer.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT07511933

• Combining olaparib with cisplatin HIPEC during interval cytoreductive surgery for ovarian cancer

  This study will test whether giving the PARP inhibitor olaparib around interval cytoreductive surgery with heated intraperitoneal cisplatin (HIPEC) is safe and feasible for adults with advanced high‑grade serous ovarian or fallopian tube cancer who responded to neoadjuvant chemotherapy.

  Recruiting Phase 1/2 The Netherlands Cancer Institute · Amsterdam · NCT07460180

• Whole-body HER2 PET/CT to see how 89Zr-trastuzumab accumulates in HER2-positive or HER2-mutated advanced NSCLC

  This study tests whether 89Zr-trastuzumab PET/CT can show how much tracer builds up in tumors of adults with HER2-positive or HER2-mutated advanced NSCLC.

  Recruiting Phase 1 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07436858

• Two-fraction MR-guided prostate radiation with lower dose to healthy prostate and a boost to MRI-visible tumor

  This will test whether giving two MRI-guided radiation sessions that lower dose to normal prostate tissue but keep a high dose to MRI-visible tumors reduces urinary and bowel side effects in men with low- or favorable-intermediate risk prostate cancer.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT07391982

• Contrast-enhanced ultrasound to locate sentinel lymph nodes during cancer surgery

  This will test whether a contrast-enhanced ultrasound scan using Sonazoid can find sentinel lymph nodes during surgery in adults with melanoma, breast cancer, or head and neck cancer.

  Recruiting Phase 2/3 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07310758

• Transtympanic sodium thiosulfate to prevent cisplatin-related hearing loss

  This trial will test whether injecting sodium thiosulfate gel into one middle ear can prevent hearing loss from cisplatin chemotherapy in adults with head and neck cancer.

  Recruiting at 2 sites Phase 3 The Netherlands Cancer Institute · Amsterdam, North Holland and 4 other locations · NCT07281508

• Short-course radiotherapy before surgery for soft tissue sarcoma

  This study tests whether a shorter course of radiation given before surgery (a 14 x 3 Gy schedule or an even shorter regimen) works as well and is safe for adults with intermediate- to high-grade soft tissue sarcoma.

  Recruiting at 2 sites The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT07071727

• Liver function after stereotactic body radiotherapy (SBRT)

  This project will use a special liver scan (HEBIS) before and after SBRT to see how different radiation doses affect liver function in people treated for liver metastases.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT07033364

• Towards optimal neoadjuvant and adjuvant systemic therapy for stage III triple-negative breast cancer

  This project will follow people with stage III triple-negative breast cancer who are starting standard (neo)adjuvant chemotherapy to see how treatments affect outcomes and quality of life and, if they agree, to track tumor DNA in blood over time.

  Recruiting at 6 sites The Netherlands Cancer Institute · Enschede, Overijssel and 8 other locations · NCT06931769

• First-line bevacizumab versus dexamethasone for symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  This trial will test whether first-line bevacizumab or dexamethasone works better at reducing symptoms in adults with symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  Recruiting at 5 sites Phase 3 The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT06888817

• Penile rehabilitation after nerve-sparing prostate surgery

  This study is testing two different ways to help men with erectile dysfunction recover after prostate surgery to see which method works better.

  Recruiting Phase 4 The Netherlands Cancer Institute · Nijmegen, Gelderland and 2 other locations · NCT06875258

• Treatment for liver metastases from colorectal cancer using a combination of therapies

  This study is testing if a new combination of treatments for liver cancer from colorectal cancer can help patients live longer compared to the standard treatment they would usually receive.

  Recruiting Phase 3 The Netherlands Cancer Institute · Amsterdam · NCT06857773

• Investigating the impact of somatostatin analogues on tumor dose during radionuclide therapy

  This study is testing if stopping or continuing long-acting somatostatin treatment affects how well radionuclide therapy works for adults with neuroendocrine tumors.

  Recruiting Phase 2/3 The Netherlands Cancer Institute · Amsterdam · NCT06855095

• Using immunotherapy to treat cutaneous squamous cell carcinoma without surgery

  This study is testing if a combination of immunotherapy drugs can help patients with skin cancer avoid surgery.

  Recruiting Phase 2 The Netherlands Cancer Institute · Maastricht, Limburg and 4 other locations · NCT06823479

• Online adaptive radiation therapy for various cancers

  This study is testing if using real-time adjustments in radiation therapy can help improve treatment for adults with prostate, cervical, bladder, lung, and head and neck cancers.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT06691776

• Radium-223 treatment for prostate cancer with bone metastases

  This study is testing if Radium-223 treatment can help men with prostate cancer that has spread to their bones and whether certain scans and blood tests can predict how well the treatment works.

  Recruiting at 4 sites The Netherlands Cancer Institute · Amsterdam, North Holland and 4 other locations · NCT06659926

• Collecting data to improve treatment for young colorectal cancer patients

  This study is collecting information from young people with early-onset colorectal cancer to see how well different treatments work and to help improve future care.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06568679

• Testing a new radiotherapy approach for non-small cell lung cancer

  This study is testing a new way of giving radiotherapy to see if it helps people with advanced non-small cell lung cancer feel better by using breaks in treatment to make the tumors more sensitive to the radiation.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT06528743

• Optimizing treatment for low stage triple-negative breast cancer patients

  This study is testing if patients with early-stage triple-negative breast cancer can skip chemotherapy after surgery and radiation if they have certain positive signs, to see how it affects their safety and quality of life.

  Recruiting at 18 sites The Netherlands Cancer Institute · Sittard-Geleen, Limburg and 27 other locations · NCT06476119

• Preoperative treatment for recurrent breast cancer using targeted radiation

  This study is testing a new way to treat women aged 51 and older with recurrent low-risk breast cancer by using targeted radiation before surgery to see if it can help them avoid a mastectomy and improve their recovery.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT06362616

• Combination of chemotherapy and immunotherapy for advanced penile cancer

  This study is testing a new treatment combining chemotherapy and immunotherapy for adults with advanced penile cancer to see if it helps them respond better to therapy and manage their disease.

  Recruiting at 2 sites Phase 2 The Netherlands Cancer Institute · Leuven and 1 other locations · NCT06353906

• New immunotherapy options for advanced triple negative breast cancer

  This study is testing a new combination of immunotherapy treatments for people with advanced triple-negative breast cancer to see if it can help them respond better to treatment.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06342037

• Testing immune therapy combinations for certain types of solid tumors

  This study is testing a combination of two immune therapy drugs to see if they can help patients with certain types of solid tumors before surgery.

  Recruiting Phase 2/3 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06279130

• Chemosensitivity across menstrual cycle phases in premenopausal triple-negative breast cancer

  This project tests whether a blood sample taken at the start of neoadjuvant chemotherapy can reveal differences in chemosensitivity related to menstrual cycle phase in premenopausal women with stage I–III triple-negative breast cancer.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06273800

• Local injection of ipilimumab and nivolumab for high-risk stage II melanoma

  This study is testing if injecting a combination of two immune-boosting drugs directly into the skin can help people with high-risk stage II melanoma by reducing the chance of cancer spreading.

  Recruiting at 2 sites Phase 1/2 The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT06240143

• Using PET/CT to Measure HER3 Levels in Lung Cancer Patients

  This study is testing a new imaging method to see how much of a specific protein called HER3 is in lung cancer patients who have already been treated, to help figure out who might benefit from a new drug.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06222489

• Neoadjuvant treatment for HER2-positive breast cancer without chemotherapy

  This study is testing a new treatment using tucatinib, trastuzumab, and pertuzumab for people with stage II-III HER2-positive breast cancer to see if they can be treated without chemotherapy.

  Recruiting Phase 1 The Netherlands Cancer Institute · Amsterdam · NCT06162559

• Combining LB-100 and Atezolizumab for Metastatic Colorectal Cancer

  This study is testing whether combining two drugs, LB-100 and atezolizumab, can help people with advanced colorectal cancer respond better to treatment.

  Recruiting Phase 1 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06012734

• Treatment for HER2-positive breast cancer with limited metastases

  This study tests if a new treatment can help people with HER2-positive breast cancer that has spread to a few other places in the body and aims to improve their chances of recovery.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam · NCT05982678

• Comparing two treatment strategies for advanced vulvar cancer

  This study is testing two different treatment plans for advanced vulvar cancer to see which one works better for patients needing intensive care.

  Recruiting at 2 sites Phase 2 The Netherlands Cancer Institute · Amsterdam and 1 other locations · NCT05905315

• Comparing two methods for preserving organs in rectal cancer patients

  This study is testing two different ways to treat rectal cancer in patients who responded well to initial treatment, to see which method helps them keep their organs and improve their quality of life.

  Recruiting at 7 sites The Netherlands Cancer Institute · Nijmegen, Gelderland and 6 other locations · NCT05772923

• Omitting radiotherapy for breast cancer patients with complete response to treatment

  This study is testing if women with early-stage breast cancer who have no signs of the disease after treatment can skip radiation therapy safely.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT05416164

• Continuing systemic therapy after local treatment for metastatic breast cancer

  This study is testing if continuing treatment after local therapies can help people with metastatic breast cancer feel better and live longer.

  Recruiting at 7 sites Phase 2 The Netherlands Cancer Institute · Alkmaar and 6 other locations · NCT05301881

• Using fecal microbiota transplantation to improve immunotherapy response in melanoma patients

  This study is testing if transferring gut bacteria from other melanoma patients can help those who haven't responded to immunotherapy feel better and improve their treatment results.

  Recruiting Phase 1/2 The Netherlands Cancer Institute · Amsterdam · NCT05251389

• Evaluating the role of lymph node dissection in prostate cancer treatment

  This study is testing if a specific surgery to remove lymph nodes can help men with intermediate- and high-risk prostate cancer do better after having their prostate removed.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT05109910

• Registry on local treatment methods for Myxoid Liposarcoma

  This study is testing different local treatment options for people with Myxoid Liposarcoma to see which methods work best.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT04699292

• Observational study on young adult cancer survivors

  This study looks at young adults who have survived cancer to see how their long-term health and quality of life are affected.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT04682470

• Neoadjuvant chemotherapy for advanced vulvar cancer

  This study tests if giving chemotherapy before surgery can help women with advanced vulvar cancer shrink their tumors and have easier surgeries.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam · NCT04192253

• Chemotherapy treatment for advanced vulvar cancer

  This study is testing if a combination of chemotherapy drugs can help shrink tumors in women with advanced vulvar cancer before surgery, making the surgery easier and safer.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam · NCT04161664

• Improving immune response in triple negative breast cancer patients

  This study is testing a combination of treatments to see if they can boost the immune response in patients with metastatic triple negative breast cancer.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam · NCT04159818

• Collecting blood samples from healthy volunteers for immune research

  This study is collecting blood samples from healthy volunteers to see how their immune cells compare to those of people with advanced cancer.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT03819829

• Pre-operative treatment for breast cancer using nivolumab and novel immunotherapies

  This study is testing whether a new combination of immunotherapy treatments can help boost the immune response in patients with early-stage breast cancer before surgery.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam · NCT03815890

• Short-term immunotherapy for early-stage colon cancer

  This study is testing a new short-term immunotherapy treatment for early-stage colon cancer to see if it can help patients stay cancer-free after surgery.

  Recruiting at 4 sites Phase 2 The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT03026140

• Access to targeted cancer therapies based on tumor genetics

  This study is testing if matching advanced cancer patients with targeted treatments based on their tumor genetics can improve their outcomes and make it easier for them to access these therapies.

  Recruiting at 34 sites Phase 2 The Netherlands Cancer Institute · Alkmaar and 35 other locations · NCT02925234

Quick answers

How many clinical trials run by The Netherlands Cancer Institute are recruiting right now?

46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in Netherlands (46 trials), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 3: 4, Phase 1: 3, Phase 2/3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →