Sponsor or institution

Clinical trials and research at Rise Therapeutics, LLC

• 3Clinical trials
• 17NIH research projects
• 1Country

Newest trials

All recruiting trials (3)

• R-5780 with PD-1 blockers for adults with advanced melanoma and other solid tumors

  This Phase 1 test will try an oral probiotic called R-5780 together with PD-1 checkpoint inhibitors to see if adults with advanced solid tumors can tolerate it safely.

  Recruiting at 2 sites Phase 1 Rise Therapeutics LLC · Denver, Colorado and 1 other locations · NCT06398418

• Testing a probiotic for patients with Rheumatoid Arthritis

  This study is testing a new probiotic to see if it can help people with Rheumatoid Arthritis feel better by reducing their symptoms.

  Recruiting at 6 sites Phase 1 Rise Therapeutics LLC · San Diego, California and 5 other locations · NCT05961592

• Testing a probiotic for mild to moderate ulcerative colitis

  This study is testing a new probiotic to see if it can help people with mild to moderate ulcerative colitis feel better and improve their gut health.

  Recruiting at 5 sites Phase 1 Rise Therapeutics LLC · Valencia, California and 4 other locations · NCT05666960

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immunology-guided probiotic therapy for Sjögren’s syndrome

  A probiotic therapy using L. lactis is being developed to help people with Sjögren’s syndrome by modulating the immune system to protect salivary and tear glands.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11575646

• Oral Microbiome–Based Aid to Immunotherapy for Refractory Solid Tumors

  A mouth-to-tumor therapy using a probiotic-like approach to help immune checkpoint drugs work better for patients whose solid tumors don’t respond well to current treatments.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11399439

• Immunotherapy using a probiotic-based treatment for rheumatoid arthritis

  A small, probiotic-based therapy taken by mouth aims to calm the immune system in people with rheumatoid arthritis to reduce joint inflammation.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11385365

• Oral immunotherapy using engineered bacteria to treat ulcerative colitis

  A new, lab-made cellular medicine using friendly gut bacteria aims to reduce inflammation in adults with ulcerative colitis and Crohn’s disease by strengthening the intestinal barrier.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11371157

• A new live bacterial therapy for Crohn’s disease

  A novel live biotherapeutic product called R-3750 is being studied to help people with Crohn’s disease by safely modulating gut immunity and restoring gut balance.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11308837

• An Oral Treatment for Ulcerative Colitis

  This project is creating a new oral medicine that uses natural gut bacteria to calm inflammation for people with inflammatory bowel disease, like ulcerative colitis.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11193481

• A New Biologic Medicine for Multiple Sclerosis

  This project aims to create a new type of medicine using the body's natural systems to help people with Multiple Sclerosis.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11142450

• Immune-directed probiotic treatment for rheumatoid arthritis

  An oral probiotic using Lactococcus lactis is being developed to calm harmful immune attacks in people with rheumatoid arthritis.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11109650

• A new probiotic treatment for rheumatoid arthritis

  This study is testing a new probiotic treatment using L. lactis to help people with rheumatoid arthritis by calming down the immune system to reduce inflammation and joint damage, with the hope of providing lasting relief from symptoms.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11076391

• A new treatment approach for Multiple Sclerosis using synthetic biology.

  This study is testing a new treatment for Multiple Sclerosis that uses the body's natural gut bacteria to help balance the immune system, with the hope of improving health and quality of life for people living with MS.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11049506

• A new oral treatment for ulcerative colitis using synthetic biology.

  This study is testing a new oral treatment that uses your body's natural gut bacteria to help reduce inflammation and improve symptoms for people with ulcerative colitis, aiming to offer a safer option than some current medications.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11007154

• A new dietary therapy using resistant starch for managing Type 1 diabetes

  This study is exploring a new way to help teenagers with Type 1 diabetes by using a special type of dietary fiber that might improve their gut health and blood sugar control, aiming to make living with diabetes a bit easier and better overall.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10906121

• Developing a new treatment using live bacteria for ulcerative colitis

  This study is testing a new treatment that uses good bacteria from your body to help reduce gut inflammation for people with ulcerative colitis and Crohn's disease, aiming to improve your gut health with fewer side effects than current options.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10894064

• A new oral drug that enhances cancer treatment by using gut bacteria.

  This study is testing a new oral drug called R-5780 to see if it can help boost the effectiveness of cancer treatments for patients with metastatic melanoma, lung, and kidney cancers by using helpful bacteria from the gut to improve their immune response.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10854788

• A new treatment using gut microbiome to help patients with severe lung injury from viruses

  This study is exploring a new way to help people with acute respiratory distress syndrome (ARDS) from viral infections by looking at how certain immune cells and gut bacteria can work together to reduce inflammation and improve recovery.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10764911

• A new probiotic treatment for Type 1 Diabetes

  This study is testing a new probiotic treatment using a friendly bacteria called Lactococcus lactis to help people with Type 1 Diabetes manage their blood sugar and improve their health by focusing on the gut.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10653229

• A new probiotic treatment for Sjögren's Syndrome

  This study is testing a new probiotic treatment to help people with Sjögren's Syndrome feel better by boosting their immune system, and it could be taken as a drink to improve daily life.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10615156

Quick answers

How many clinical trials run by Rise Therapeutics, LLC are recruiting right now?

3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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