A new probiotic treatment for Type 1 Diabetes
Official title: A Novel Immunologically Directed Probiotic for the Treatment of Type 1 Diabetes
Funded at Rise Therapeutics, LLC · NIH-10653229 · Data updated 2026-11-12
This study is testing a new probiotic treatment using a friendly bacteria called Lactococcus lactis to help people with Type 1 Diabetes manage their blood sugar and improve their health by focusing on the gut.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rise Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Rockville, UNITED STATES) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $983,580 |
| NIH project number | 5R44DK134274-02 |
| Project ID | NIH-10653229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes who are seeking alternative treatment options beyond insulin therapy.
✕Less likely to help
Patients who do not have Type 1 Diabetes or those who are not responsive to probiotic treatments may not benefit from this research.
What this research studies
This research aims to develop a novel probiotic therapy using Lactococcus lactis to treat Type 1 Diabetes (T1D). The approach focuses on harnessing the gut microbiome's immune regulatory mechanisms to improve glycemic control and overall patient well-being. By targeting the gut, this therapy seeks to address the underlying immunological issues associated with T1D, potentially reducing the risk of complications such as kidney failure and stroke. Patients will be monitored for changes in their immune response and overall health as part of the treatment process.
Why it matters
Potential benefit: If successful, this research could provide a new, non-invasive treatment option for managing Type 1 Diabetes and improving patients' quality of life.
How similar studies have gone: Previous studies have shown that fecal microbiome therapy can halt the progression of new onset Type 1 Diabetes, indicating potential success for this novel probiotic approach.
Where this research is happening
-
Rise Therapeutics, LLC
Rockville, United States Active
Researchers
- Principal investigator: Furlan Freguia, Christian — Rise Therapeutics, LLC
- Study coordinator: Furlan Freguia, Christian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.