A new dietary therapy using resistant starch for managing Type 1 diabetes
Official title: R-5280, A Novel Modified Superior Resistant Starch Therapy for Type 1 Diabetes
Funded at Rise Therapeutics, LLC · NIH-10906121 · Data updated 2026-11-12
This study is exploring a new way to help teenagers with Type 1 diabetes by using a special type of dietary fiber that might improve their gut health and blood sugar control, aiming to make living with diabetes a bit easier and better overall.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rise Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Rockville, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $995,869 |
| NIH project number | 5R44DK137649-02 |
| Project ID | NIH-10906121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents under 16 years of age diagnosed with Type 1 diabetes.
✕Less likely to help
Patients over the age of 16 or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates a novel therapy using modified resistant starch to improve management of Type 1 diabetes (T1D) in adolescents. The approach focuses on how dietary fiber, specifically high amylose starch, can positively influence the gut microbiome and immune response, potentially leading to better glycemic control and overall quality of life. By examining the effects of this dietary intervention, the study aims to provide a new strategy for T1D management that goes beyond insulin therapy. Participants will be monitored for changes in their gut microbiota and related health outcomes.
Why it matters
Potential benefit: If successful, this research could offer a new dietary treatment option that improves glycemic control and quality of life for adolescents with Type 1 diabetes.
How similar studies have gone: Previous studies have shown promising results with dietary interventions like fecal microbiome therapy and probiotics in managing Type 1 diabetes, suggesting that this approach may also be effective.
Where this research is happening
-
Rise Therapeutics, LLC
Rockville, United States Active
Researchers
- Principal investigator: Furlan Freguia, Christian — Rise Therapeutics, LLC
- Study coordinator: Furlan Freguia, Christian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.