Sponsor or institution
Clinical trials and research at Palo Alto Veterans Instit for Research
As of November 12, 2026, Find a Trial lists 49 NIH-funded research projects at this institution, with $26.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 49NIH research projects
NIH-funded research (newest 40 of 49)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Stopping heart-protecting medicines for older veterans with and without Alzheimer's in nursing homes
This project compares outcomes when common heart-protecting medicines like aspirin and statins are stopped versus continued for older VA nursing home residents with and without Alzheimer's disease.
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Age-related ketogenesis and liver–gut health in aging
Aging adults may benefit from new insights into how the liver and gut communicate, and whether boosting ketone production can reduce inflammation and improve liver and gut function.
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dTMS treatment targeting brain networks to help adults with alcohol use disorder
This NIH grant tests whether deep transcranial magnetic stimulation can boost brain activity in key areas and reduce drinking in adults with alcohol use disorder.
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Virtually Supervised Exercise for Kidney Transplant Candidates
A home-based, online-guided exercise program helps people waiting for a kidney transplant stay stronger and fitter.
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Virtually supervised exercise program for people waiting for a kidney transplant
This project offers a home-based, virtually supervised exercise program to help people on the kidney transplant waitlist keep and rebuild muscle and stay more mobile.
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Neural immunoregulation of post-traumatic autoimmunity
A patient-facing summary describing how the immune system may contribute to chronic pain after injuries, with the goal of finding better ways to relieve long-lasting back and joint pain.
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Proteostasis and Proteotoxicity Mechanisms in Alzheimer’s Disease
Researchers are looking at how faulty protein folding drives Alzheimer’s disease and how the cell's quality-control system could be targeted to help patients.
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Understanding how the heart’s arteries grow and change to guide new CAD treatments
This NIH grant explores basic human biology to discover how coronary arteries form and adapt, with the aim of someday helping people with coronary artery disease.
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Bioengineered conduit to prevent lymphedema after cancer surgery
A new resorbable conduit implanted during surgery could help prevent lymphedema in cancer survivors by bridging lymphatic obstructions.
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Intestinal immune cells and how they reach the gut
A study to understand how special gut T cells get into the intestines before birth and how they help protect newborns, with potential implications for human gut immunity and disease.
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Blood-vessel gateway cells that guide immune cells into lymph nodes
This project looks at how special blood-vessel cells form and change to let immune cells enter lymph nodes during inflammation, which matters for people with autoimmune disease and atherosclerosis.
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Safely stopping heart-prevention medicines for nursing home residents with and without Alzheimer's
This project will see if stopping common heart-prevention medicines like aspirin and statins is safer and more helpful for nursing home residents aged 65 and older with and without Alzheimer's disease.
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Could vaping increase abdominal aortic aneurysm risk across generations
This project looks at whether parents' vaping or nicotine exposure can cause biological changes that make their children more likely to develop abdominal aortic aneurysms.
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Online yoga vs. acceptance-based therapy for chronic musculoskeletal pain in veterans
A large, well-designed study will compare online yoga to acceptance and commitment therapy to help veterans manage chronic musculoskeletal pain.
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Understanding how the immune system affects chronic back pain
A research study is exploring how immune system signals and antibodies contribute to low back pain and how this could lead to better treatments for people with persistent back pain.
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A newly discovered immune receptor that guides lymphocytes to lungs and mucosal tissues
This project looks at how a newly found receptor and its partner guide immune cells into the lungs and other mucosal organs to better understand inflammation in autoimmune conditions.
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Why some patients with cirrhosis miss recommended liver cancer screening
This project looks at why African American, Hispanic, and non-English-speaking patients with cirrhosis are less likely to get recommended liver cancer screening and how the COVID-19 pandemic changed that.
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Mutant calreticulin in certain blood cancers (MPN)
Looking for new treatments that target a mutant protein called calreticulin to help people with CALR‑mutant myeloproliferative neoplasms.
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Understanding how family genetics affect Alzheimer's risk
A scientist team is studying how inherited genetic patterns in families with consanguinity influence Alzheimer’s disease risk and progression.
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At-home guided exercise program for people awaiting a kidney transplant
A home-based, video-supervised exercise program to help people waiting for a kidney transplant stay stronger and more mobile.
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How nerve–immune signals cause autoimmune pain after injury
Looks at whether nerve-driven immune reactions and antibodies cause long-lasting pain after injuries in people with conditions like CRPS, chronic low back pain, or osteoarthritis.
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Understanding Blood Pressure Targets for Adults with Kidney Disease
This project looks at existing information to find the best blood pressure goals for adults living with chronic kidney disease.
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How coronary artery shapes form and could guide new treatments for blocked heart arteries
This project is looking for genes and biological signals that explain different coronary artery shapes to help find ways to grow or reroute heart blood vessels for people with coronary artery disease.
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A Bioengineered Treatment to Prevent Lymphedema
This project aims to create a special implant to help prevent lymphedema, a condition where fluid builds up, often after cancer treatment.
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Understanding how a protein called SIRT7 affects aging and cancer
This research explores how a specific protein, SIRT7, controls cell processes that are important in both aging and the development of cancer.
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Stopping unnecessary heart medications in older adults with Alzheimer's disease and related dementias
This study is looking at whether stopping certain heart medications is safe and helpful for older nursing home residents with Alzheimer's and similar conditions, to see if it can improve their health and well-being.
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Stopping unnecessary heart medications in older adults with Alzheimer's disease and related dementias
This study is looking at whether stopping certain heart medications, like aspirin and statins, can be helpful for older nursing home residents with Alzheimer's and similar conditions, to see if it might reduce risks without losing important benefits.
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Chromatin helpers to protect aging and metabolic health
A study in mice and cells will look at how a specific protein, SIRT7, controls DNA packaging and metabolism as we age, with the aim of finding ways to prevent aging-related diseases.
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How e-cigarettes may affect the risk of abdominal aortic aneurysms across generations
This study is looking at how using e-cigarettes and being exposed to nicotine might lead to a serious condition called abdominal aortic aneurysms (AAAs), and it aims to understand how these factors could cause changes in genes that might affect not just the person using e-cigarettes, but also their children.
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Understanding Gut Immune Cells in Babies
This research explores how important immune cells called T cells develop in the gut of babies, even before birth, to protect against infections and prevent allergies and autoimmune conditions.
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How Alzheimer's disease affects gut health and movement
This study looks at how problems in the gut, like constipation, might be linked to Alzheimer's disease, hoping to find out how changes in the gut can affect brain health in older adults.
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Investigating how B lymphocytes affect pain after trauma
This study is looking at how certain immune cells called B lymphocytes might affect long-lasting pain and recovery after injuries like broken bones, and it aims to find ways to help people feel better and heal faster.
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Investigating how mutant calreticulin affects blood cell disorders
This study is looking at how certain changes in a protein called calreticulin affect blood cancers known as myeloproliferative neoplasms, with the hope of finding new ways to treat these conditions and improve patients' lives.
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Understanding how immune cells move to different tissues in the body
This study is looking at how certain immune cells find their way to different parts of the body, especially the lungs, and it’s exploring a new receptor that helps guide these cells, which could lead to better treatments for autoimmune diseases and chronic inflammation that many patients face.
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Comparing online yoga and therapy for chronic pain relief
This study is looking at whether online yoga can help reduce chronic pain just as well as a type of therapy called Acceptance and Commitment Therapy (ACT), especially for veterans who might not have easy access to regular healthcare.
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Exploring genetic links to Alzheimer's disease in Pakistan's consanguineous population
This study is looking at how genetics might play a role in Alzheimer's disease by working with families in Pakistan where cousins often marry, and it aims to gather information from participants to help find better ways to prevent and treat dementia.
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Understanding why some patients with cirrhosis receive less screening for liver cancer than others
This study looks at why some people with liver cirrhosis, especially from minority and underserved groups, aren't getting screened for liver cancer as often as they should, especially during and after the COVID-19 pandemic, and aims to find ways to make it easier for everyone to get the care they need.
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Understanding how coronary arteries develop and function
This study is looking at how our hearts develop blood vessels and how we can use that knowledge to find new ways to help people with coronary artery disease feel better and improve their heart health.
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Creating a device to prevent lymphedema after cancer treatment
This study is testing a new device that could help prevent lymphedema, which causes swelling in breast cancer survivors, by using a special implant to improve lymph fluid flow and tackle the problem at its source.
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Understanding how histone modifications affect aging and cancer
This study is looking at how a specific enzyme called SIRT7 affects our genes and how this might relate to aging and cancer, with the hope of finding new ways to help people stay healthier as they get older.
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