Understanding how histone modifications affect aging and cancer
Official title: Histone Deacetylation Signaling in Aging and Cancer Pathways
Funded at Palo Alto Veterans Instit for Research · NIH-10977427 · Data updated 2026-11-12
This study is looking at how a specific enzyme called SIRT7 affects our genes and how this might relate to aging and cancer, with the hope of finding new ways to help people stay healthier as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | July 9, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $65,899 |
| NIH project number | 3R01CA268925-04S1 |
| Project ID | NIH-10977427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals experiencing age-related health issues or those at risk for age-associated cancers.
✕Less likely to help
Patients with non-age-related conditions or those not affected by cancer may not receive direct benefits from this research.
What this research studies
This research investigates the role of histone deacetylation in regulating chromatin and its implications for aging and cancer. By studying the enzyme SIRT7, the project aims to uncover how changes in histone modifications can lead to genomic instability and age-related diseases. The research utilizes animal models to explore the effects of SIRT7 on lifespan and cellular health, providing insights into potential therapeutic targets for age-associated conditions and cancer. Patients may benefit from findings that could lead to new treatments or preventive strategies for aging-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating age-related diseases and certain cancers.
How similar studies have gone: Other research has shown promising results in understanding the role of histone modifications in aging and cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Palo Alto Veterans Instit for Research
Palo Alto, United States Active
Researchers
- Principal investigator: Chua, Katrin F — Palo Alto Veterans Instit for Research
- Study coordinator: Chua, Katrin F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.