Investigating how mutant calreticulin affects blood cell disorders
Official title: Functional and Molecular Dissection of Mutant Calreticulin in Myeloproliferative Neoplasms
Funded at Palo Alto Veterans Instit for Research · NIH-11060153 · Data updated 2026-11-12
This study is looking at how certain changes in a protein called calreticulin affect blood cancers known as myeloproliferative neoplasms, with the hope of finding new ways to treat these conditions and improve patients' lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | May 20, 2024 |
| Project end | September 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $355,000 |
| NIH project number | 7R01HL131835-09 |
| Project ID | NIH-11060153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms associated with calreticulin mutations.
✕Less likely to help
Patients without calreticulin mutations or those with other types of blood disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of calreticulin mutations in myeloproliferative neoplasms (MPN), a group of blood cancers. The team aims to identify unique properties of hematopoietic stem cells that carry these mutations, which may lead to new therapeutic strategies. By exploring the biochemical changes and dependencies of these mutant cells, the researchers hope to uncover vulnerabilities that can be targeted for treatment. The ultimate goal is to develop innovative therapies that could modify the disease and potentially cure it.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with calreticulin-mutant MPN.
How similar studies have gone: Previous research has shown promise in targeting specific mutations in blood cancers, indicating that this approach may lead to successful outcomes.
Where this research is happening
-
Palo Alto Veterans Instit for Research
Palo Alto, United States Active
Researchers
- Principal investigator: Mullally, Ann — Palo Alto Veterans Instit for Research
- Study coordinator: Mullally, Ann
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This grant explores how two CALR mutation types cause myeloproliferative neoplasms and could lead to better treatments for people with these blood cancers.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.