Investigating how mutant calreticulin affects blood cell disorders
Functional and Molecular Dissection of Mutant Calreticulin in Myeloproliferative Neoplasms
['FUNDING_R01'] · PALO ALTO VETERANS INSTIT FOR RESEARCH · NIH-11060153
This study is looking at how certain changes in a protein called calreticulin affect blood cancers known as myeloproliferative neoplasms, with the hope of finding new ways to treat these conditions and improve patients' lives.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PALO ALTO VETERANS INSTIT FOR RESEARCH (nih funded) |
| Locations | 1 site (PALO ALTO, UNITED STATES) |
| Trial ID | NIH-11060153 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of calreticulin mutations in myeloproliferative neoplasms (MPN), a group of blood cancers. The team aims to identify unique properties of hematopoietic stem cells that carry these mutations, which may lead to new therapeutic strategies. By exploring the biochemical changes and dependencies of these mutant cells, the researchers hope to uncover vulnerabilities that can be targeted for treatment. The ultimate goal is to develop innovative therapies that could modify the disease and potentially cure it.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms associated with calreticulin mutations.
Not a fit: Patients without calreticulin mutations or those with other types of blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with calreticulin-mutant MPN.
How similar studies have performed: Previous research has shown promise in targeting specific mutations in blood cancers, indicating that this approach may lead to successful outcomes.
Where this research is happening
PALO ALTO, UNITED STATES
- PALO ALTO VETERANS INSTIT FOR RESEARCH — PALO ALTO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULLALLY, ANN — PALO ALTO VETERANS INSTIT FOR RESEARCH
- Study coordinator: MULLALLY, ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.