Understanding Blood Pressure Targets for Adults with Kidney Disease
Official title: Applying Hypertension Clinical Trials to Real World Adults with CKD
Funded at Palo Alto Veterans Instit for Research · NIH-11143880 · Data updated 2026-11-12
This project looks at existing information to find the best blood pressure goals for adults living with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | September 24, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $596,163 |
| NIH project number | 5R01DK128108-05 |
| Project ID | NIH-11143880 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project focuses on adults aged 21 and older who have chronic kidney disease and high blood pressure, particularly those who might be similar to participants in previous large blood pressure studies.
✕Less likely to help
Patients without chronic kidney disease or high blood pressure would not directly benefit from the findings of this specific project.
What this research studies
Many adults with chronic kidney disease also have high blood pressure, and finding the right treatment is very important. Doctors currently have different ideas about the best blood pressure targets for these patients. This project will carefully look at health records from millions of people and combine that with information from past blood pressure studies. The goal is to understand the real-world benefits and risks of different blood pressure goals for people with kidney disease.
Why it matters
Potential benefit: If successful, this work could help doctors provide clearer, more personalized recommendations for blood pressure management in adults with chronic kidney disease, potentially improving their health outcomes.
How similar studies have gone: This project builds upon the strong evidence from previous randomized controlled trials like SPRINT, extending their findings to a broader, real-world patient population.
Where this research is happening
-
Palo Alto Veterans Instit for Research
Palo Alto, United States Active
Researchers
- Principal investigator: Kurella Tamura, Manjula — Palo Alto Veterans Instit for Research
- Study coordinator: Kurella Tamura, Manjula
Related research
Other NIH-funded projects on the same topics.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Coaching and Navigation by Community Health Workers via Telehealth for High-Risk Hypertension
A program using telehealth and community health workers to help adults with severe hypertension connect to primary care and follow practical, heart-healthy lifestyle tips.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.