Understanding how coronary arteries develop and function
Official title: Intersecting clinical, genomic, and experimental investigation to understand the mechanisms and impact of coronary artery patterning
Funded at Palo Alto Veterans Instit for Research · NIH-10980396 · Data updated 2026-11-12
This study is looking at how our hearts develop blood vessels and how we can use that knowledge to find new ways to help people with coronary artery disease feel better and improve their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $703,368 |
| NIH project number | 1R01HL171326-01A1 |
| Project ID | NIH-10980396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with advanced coronary artery disease who may benefit from novel treatment approaches.
✕Less likely to help
Patients with early-stage coronary artery disease or those without significant anatomical variations in their coronary arteries may not receive benefit from this research.
What this research studies
This research investigates the mechanisms behind coronary artery development and how these processes can be harnessed to create new treatments for coronary artery disease (CAD). The approach involves studying the genetic factors that influence coronary artery formation during early development and identifying pathways that could be targeted to promote artery growth or natural bypasses in patients with advanced CAD. By analyzing variations in coronary artery anatomy within the population, the researchers aim to uncover potential therapeutic strategies that could lead to innovative treatments for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance coronary artery growth and improve outcomes for patients with coronary artery disease.
How similar studies have gone: While the concept of medical revascularization is innovative, previous studies have shown promise in understanding coronary artery development, suggesting potential for success in this area.
Where this research is happening
-
Palo Alto Veterans Instit for Research
Palo Alto, United States Active
Researchers
- Principal investigator: Assimes, Themistocles Leonard — Palo Alto Veterans Instit for Research
- Study coordinator: Assimes, Themistocles Leonard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.