Sponsor or institution

Clinical trials and research at Ottawa Heart Institute Research Corporation

• 36Clinical trials
• 6Countries

Newest trials

All recruiting trials (36)

• Feasibility check of skeletonized vs non-skeletonized left internal mammary artery harvesting in heart surgery

  This pilot test compares two ways of taking the left internal mammary artery during CABG to see which approach is feasible to study further and how it affects graft patency and patient experience.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07599553

• Improving transition of congenital heart disease care from pediatric to adult services

  This program will try a multi-step transfer process to reduce health declines in people with congenital heart disease who are waiting to see an adult specialist.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07585175

• Mental health and quality of life after ICU treatment with dexmedetomidine for electrical storm

  This follows people treated for electrical storm in the ICU to see if receiving dexmedetomidine is linked to their mental health and quality of life 3–6 months later.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07368062

• Pericardial inflammation imaging to predict recurrent pericarditis

  Doctors are testing imaging tools to see if FDG PET/CT and MRI can predict which patients with recurrent pericarditis will flare again.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07245849

• Semaglutide to help people with type 2 diabetes quit smoking

  This pilot will test whether adding semaglutide to combination nicotine replacement helps adults with type 2 diabetes quit smoking and limits post-quit weight gain.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07059377

• Using a quick CT scan to check for left atrial clots before cardioversion in the Emergency Department

  This will test whether a rapid cardiac CT in the ED to look for left atrial clots lets people with symptomatic atrial fibrillation or flutter have safe same‑day cardioversion instead of being admitted or delayed.

  Recruiting at 3 sites Ottawa Heart Institute Research Corporation · Hershey, Pennsylvania and 2 other locations · NCT07002450

• Combining nicotine replacement therapy and medications for quitting smoking

  This study is testing whether smokers are willing to join a quit smoking program that combines counseling with different products to help them stop smoking over a year.

  Recruiting Phase 4 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06832085

• Reducing artery inflammation after community-acquired pneumonia

  This trial will test whether taking Vascepa twice daily for six months can reduce artery inflammation in adults hospitalized with community-acquired pneumonia.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06710080

• Comparing two methods for assessing patent foramen ovale in stroke patients

  This study is testing if a guided breathing technique works better than a self-directed one for checking a heart condition in stroke patients to help improve diagnosis and reduce the chance of future strokes.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario and 1 other locations · NCT06670781

• Comparing higher-energy versus standard biphasic shocks for cardioversion of atrial fibrillation

  This trial will test whether using a 360J biphasic defibrillator works better than a 200J device to restore normal heart rhythm in adults with persistent atrial fibrillation scheduled for elective cardioversion.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06556667

• Left atrial shunt to help after mitral valve surgery

  This study tests whether making a small opening between the left and right atria during mitral valve repair can relieve high left atrial pressure for adults with primary mitral regurgitation.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06547788

• Exercise training for women with heart disease

  This project will test whether virtual high-intensity interval training (HIIT) or virtual moderate-to-vigorous continuous training (MICT) better improves fitness, mental health, and quality of life in women with coronary heart disease.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06494163

• Midodrine in heart failure with reduced ejection fraction and low blood pressure

  This study tests whether adding midodrine helps patients with HFrEF and hypotension when standard heart failure therapy is limited by low blood pressure.

  Recruiting Phase 2/3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06405555

• Evaluating dexmedetomidine for treating electrical storm in patients

  This study is testing if a sedative called dexmedetomidine can help adults with electrical storm, which causes dangerous heart rhythms, by reducing these episodes and improving their recovery.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Rochester, Minnesota and 1 other locations · NCT06281977

• Comparing four treadmill exercise protocols in women and men with coronary artery disease

  This project tests four treadmill exercise tests to see if women and men with coronary artery disease reach different peak oxygen use (VO2 peak).

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06179212

• Using dapagliflozin to reduce heart damage in STEMI patients

  This study is testing if the medication dapagliflozin can help reduce heart damage in patients who have just had a heart attack and are receiving treatment.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06174753

• Using a new imaging agent to detect inflamed plaque in heart and brain patients

  This study is testing a new imaging agent to see if it can help spot inflamed plaque in patients who have recently had a heart attack or stroke.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06091319

• Using PET scans to monitor heart transplant patients for complications

  This study is testing if regular PET scans can safely monitor heart transplant patients for complications instead of the usual invasive procedures.

  Recruiting Ottawa Heart Institute Research Corporation · Calgary, Alberta and 4 other locations · NCT06089486

• Using canagliflozin to reduce vascular inflammation in patients with diabetes and coronary artery disease

  This study is testing if the medication canagliflozin can help reduce inflammation in the blood vessels of people with diabetes and coronary artery disease.

  Recruiting Phase 2/3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT05427084

• Repairing the mitral valve in patients with cardiogenic shock

  This study tests if a new heart procedure called TEER can help patients in cardiogenic shock with leaky mitral valves feel better compared to standard treatments.

  Recruiting at 2 sites Ottawa Heart Institute Research Corporation · Rochester, Minnesota and 3 other locations · NCT05298124

• Comparing heart medications for patients in cardiogenic shock

  This study tests whether two heart medications, Dobutamine and Milrinone, can help critically ill patients in cardiogenic shock feel better compared to a placebo.

  Recruiting at 2 sites Phase 4 Ottawa Heart Institute Research Corporation · Rochester, Minnesota and 2 other locations · NCT05267886

• Improving quality of life for patients with persistent atrial fibrillation

  This study is testing if a procedure to restore normal heart rhythm can help improve the quality of life for people with persistent atrial fibrillation.

  Recruiting at 2 sites Ottawa Heart Institute Research Corporation · Newmarket, Ontario and 1 other locations · NCT05136131

• Comparing catheter ablation and non-invasive radio ablation for ventricular tachycardia

  This study is testing a new non-invasive treatment for ventricular tachycardia to see if it works better and is safer than the standard catheter ablation for older patients who have had repeated issues.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT05047198

• Registry for heart inflammation after COVID-19 vaccination

  This study is trying to collect information about heart inflammation cases, like myocarditis and pericarditis, that might happen after COVID-19 vaccination to better understand how it affects patients.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT05046002

• Comparing lenient and strict arm instructions after heart device surgery

  This study tests whether allowing more movement with the arms after heart device surgery can improve recovery and reduce complications for patients.

  Recruiting Phase 4 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT04915261

• Personalized wide-area radiofrequency ablation plus pulmonary vein isolation versus pulsed-field pulmonary vein isolation for paroxysmal atrial fibrillation

  This trial will test whether a patient-tailored radiofrequency ablation that targets extra atrial sources plus pulmonary vein isolation prevents recurrent atrial fibrillation better than pulsed-field pulmonary vein isolation in adults with paroxysmal AF.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario and 1 other locations · NCT04823299

• Investigating antiplatelet therapy to prevent complications in heart transplant patients

  This study tests if giving heart transplant patients early treatment with aspirin or clopidogrel can help prevent a common problem where their heart arteries narrow.

  Recruiting at 3 sites Phase 3 Ottawa Heart Institute Research Corporation · Vancouver, British Columbia and 2 other locations · NCT04770012

• Helping smokers quit during emergency department visits

  This study is testing a new way to help daily smokers quit by giving them support and incentives during their emergency department visits to see if it helps them stay smoke-free for longer.

  Recruiting at 4 sites Ottawa Heart Institute Research Corporation · Ottawa, Ontario and 3 other locations · NCT04163081

• Hemiarch versus extended arch repair for acute DeBakey type 1 aortic dissection

  This study will test whether an extended arch repair or the standard hemiarch repair leads to fewer deaths and fewer repeat operations in adults needing emergency surgery for acute DeBakey type 1 aortic dissection.

  Recruiting at 5 sites Ottawa Heart Institute Research Corporation · London, Ontario and 4 other locations · NCT03885635

• Comparing low dose Prednisone and Methotrexate to standard dose Prednisone for cardiac sarcoidosis

  This study is testing whether a low dose of Prednisone combined with Methotrexate can help people with cardiac sarcoidosis just as well as a standard dose of Prednisone, while also making them feel better and reducing side effects.

  Recruiting at 26 sites Phase 3 Ottawa Heart Institute Research Corporation · New Haven, Connecticut and 30 other locations · NCT03593759

• Comparing surgery and monitoring for ascending aortic aneurysms

  This study tests whether early surgery or careful monitoring is better for people aged 18 to 79 with asymptomatic ascending aortic aneurysms that are between 5.0 cm and 5.4 cm.

  Recruiting at 28 sites Ottawa Heart Institute Research Corporation · San Francisco, California and 30 other locations · NCT03536312

• Exercise training for patients with atrial fibrillation

  This study is testing whether high-intensity interval training or moderate exercise can help people with atrial fibrillation feel better and improve their quality of life compared to standard care.

  Recruiting at 2 sites Ottawa Heart Institute Research Corporation · London, Ontario and 1 other locations · NCT03397602

• Using biomarkers to guide the discharge of heart failure patients from the hospital

  This study is testing if using specific blood tests can help doctors decide when it's safe to send heart failure patients home from the hospital, compared to standard care.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT03103932

• Comparing mild and moderate hypothermia during aortic hemiarch surgery

  This study is testing if keeping patients at a slightly warmer temperature during heart surgery can help them recover better and spend less time on the heart-lung machine compared to a cooler temperature.

  Recruiting at 10 sites Ottawa Heart Institute Research Corporation · Boston, Massachusetts and 11 other locations · NCT02860364

• Identifying early signs of atrial fibrillation in patients with heart devices

  This study is trying to find early signs of irregular heartbeats in people with pacemakers or defibrillators to see if certain markers can help predict who might develop atrial fibrillation.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT02808260

• Observing cardiac sarcoidosis in patients

  This study looks at patients with cardiac sarcoidosis and those at risk for it to see how the disease progresses and how treatments like corticosteroids affect them.

  Recruiting at 13 sites Ottawa Heart Institute Research Corporation · Calgary, Alberta and 13 other locations · NCT01477359

Quick answers

How many clinical trials run by Ottawa Heart Institute Research Corporation are recruiting right now?

36, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Canada (36 trials), United States (7 trials), Japan (2 trials), Sweden (1 trial), New Zealand (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 8, Phase 4: 3, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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