Comparing catheter ablation and non-invasive radio ablation for ventricular tachycardia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares two treatment methods for ventricular tachycardia: the standard catheter ablation and a novel non-invasive radio ablation technique using ECG-based body surface mapping. The goal is to determine the effectiveness of non-invasive radio ablation in targeting and treating ventricular tachycardia circuits without the complications associated with invasive procedures. Patients aged 55 and older with recurrent VT despite previous treatments will be enrolled. The study aims to provide a safer alternative for patients at high risk of complications from traditional catheter ablation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient aged ≥55 years of age
2. Cardiomyopathy (Left ventricular ejection fraction ≤ 35% and ICD in situ) AND
3. Recurrent VT events despite previous CA OR
4. VT events requiring intervention and PAINESD score ≥ 15

Exclusion Criteria:

1. Patients with NYHA Class IV heart failure \&/ or with LVAD in situ
2. Patients not expected to live for more than one year for any reason
3. Patients who have previously received thoracic radiotherapy
4. Patients who are enrolled in another randomized clinical trial
5. Patients who are unable or unwilling to provide informed consent
6. Patients aged ≤54 years of age
7. Pregnancy (all women of child bearing age and potential will have a negative β-HCG test before enrollment)
8. Breastfeeding
9. Women of childbearing age who refuse to use a highly effective and medically acceptable form of contraception (IUD, sterilization, birth control implant or birth control pill) throughout the study.

Where it's running

• University of Ottawa Heart Institute
  Ottawa, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Calum Redpath — Ottawa Heart Institute Research Corporation
• Study coordinator: Calum Redpath
• Email: credpath@ottawaheart.ca
• Phone: 6136967000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.