Exercise training for patients with atrial fibrillation
Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation - a Multi-centre Randomized Controlled Trial
NA · Ottawa Heart Institute Research Corporation · NCT03397602
This study is testing whether high-intensity interval training or moderate exercise can help people with atrial fibrillation feel better and improve their quality of life compared to standard care.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 132 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Ottawa Heart Institute Research Corporation (other) |
| Locations | 2 sites (London, Ontario and 1 other locations) |
| Trial ID | NCT03397602 on ClinicalTrials.gov |
What this trial studies
This project evaluates the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. The study aims to provide evidence supporting the inclusion of exercise in the management of atrial fibrillation, which is often overlooked in standard care. By comparing different exercise modalities, the research seeks to identify effective interventions that can improve patient outcomes and overall well-being. The findings could lead to new recommendations for cardiac rehabilitation in this patient population.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40 and older with persistent or permanent atrial fibrillation who are rate controlled.
Not a fit: Patients currently engaged in routine exercise training more than twice a week or those with severe cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve exercise capacity and quality of life for patients with atrial fibrillation.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in similar patient populations, suggesting a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. persistent or permanent atrial fibrillation; 2. rate controlled with a resting ventricular rate of equal to or less than 100 bpm; 3. able to perform a symptom-limited exercise test; 4. at least 40 years of age (i.e. participants must be 40 years or older); Exclusion Criteria: 1. currently participating in routine exercise training (more than two times per week); 2. unstable angina; 3. diagnosed severe mitral or aortic stenosis; 4. diagnosed hypertrophic obstructive cardiomyopathy with significant obstruction; 5. pregnant, lactating or planning to become pregnant during the study period; 6. unable to provide written, informed consent, or 7. unwilling or unable to return for follow up at week 12.
Where this trial is running
London, Ontario and 1 other locations
- London Health Sciences Network — London, Ontario, Canada (RECRUITING)
- University of Ottawa Heart Insititue — Ottawa, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Jennifer L Reed, PhD — Ottawa Heart Institute Research Corporation
- Study coordinator: Jennifer L Reed, PhD
- Email: jreed@ottawaheart.ca
- Phone: 613-696-7392
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Atrial Fibrillation, atrial fibrillation, exercise