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Clinical trials and research at Milton S. Hershey Medical Center

• 42Clinical trials
• 6Countries

Newest trials

All recruiting trials (42)

• Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

  This trial tests whether adding eflornithine (DFMO) as extra or maintenance therapy can improve survival for young people with Ewing sarcoma or osteosarcoma.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Tampa, Florida and 2 other locations · NCT07321912

• College student–delivered cognitive behavioral therapy for rural high school students

  This project will test whether cognitive-behavioral therapy delivered by trained college students can help high school students in rural Schuylkill County who have symptoms of depression, anxiety, or stress.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT07240792

• An AI chatbot to help teens and young adults with eating disorders manage anxiety about weight gain

  This project will test an AI-powered chatbot that delivers exposure-based exercises to help adolescents and young adults in a partial hospitalization program reduce anxiety about weight gain.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT07237607

• Virtual exposure treatment for adolescents with anorexia nervosa

  This project will try virtual exposure therapy to help 14–17-year-olds with anorexia nervosa face and tolerate anxiety about weight gain.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT07188155

• CBG/CBD oil for chemotherapy-induced peripheral neuropathy

  This will try a CBG/CBD oil to see if it safely reduces pain, numbness, or other nerve symptoms in adults who developed peripheral neuropathy after platinum-based chemotherapy for gastrointestinal cancers.

  Recruiting Phase 1 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT07016971

• Allogeneic stem cell transplant with low-dose post-transplant cyclophosphamide to prevent graft-versus-host disease.

  This study tests whether giving low-dose (25 mg/kg) cyclophosphamide on days +3 and +4 after allogeneic peripheral blood stem cell transplant can prevent GVHD in adults with blood cancers who receive reduced-intensity or non-myeloablative conditioning.

  Recruiting Phase 2 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06926595

• What predicts improvement in irritability and aggression in children with ADHD on stimulant medication

  This study sees if optimizing stimulant medication helps children with ADHD who have high irritability and aggression and whether brain and learning tests can predict who improves.

  Recruiting Phase 4 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06871488

• Stories to Prevent HPV Cancers

  We will try short videos of local cancer survivors telling their HPV stories to see if parents of 9- to 12-year-olds are more likely to start the HPV vaccine for their children.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06808776

• Helping seniors with osteoarthritis use their SilverSneakers fitness benefits

  We will test whether a brief outreach with mailed materials and two phone calls helps older adults with osteoarthritis start using their SilverSneakers benefits, improve physical and social well-being, and reduce related healthcare use.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06782347

• Using SVC-CI to Predict Fluid Needs in Heart Surgery Patients

  This study is testing if a new measurement called SVC-CI can help doctors predict how much fluid heart surgery patients will need during their operation.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06645327

• Evaluating the safety and effectiveness of INM176 for prostate cancer patients with rising PSA levels

  This study is testing if the herbal supplement INM176 can help prostate cancer patients with rising PSA levels feel better and stabilize their condition.

  Recruiting Phase 1/2 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06600698

• Yoga to reduce endometriosis-related pelvic pain

  This 12-week program will test if practicing yoga can reduce pelvic pain in women aged 18–45 with surgically confirmed endometriosis.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06559852

• Using semaglutide to help reduce opioid use in patients undergoing treatment for opioid use disorder

  This study is testing if the medication semaglutide can help adults in outpatient treatment for opioid use disorder reduce their use of illicit opioids.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Baltimore, Maryland and 3 other locations · NCT06548490

• Using silmitasertib with chemotherapy for relapsed solid tumors

  This study is testing a new drug called silmitasertib combined with chemotherapy to see if it helps people with relapsed solid tumors feel better and manage their cancer.

  Recruiting at 24 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 23 other locations · NCT06541262

• Combining tipifarnib and naxitimab for treating relapsed neuroblastoma

  This study is testing a new combination of an oral drug called tipifarnib and an intravenous drug called naxitimab to see if it can help children with relapsed neuroblastoma.

  Recruiting at 12 sites Phase 2 Milton S. Hershey Medical Center · Little Rock, Arkansas and 11 other locations · NCT06540963

• Effects of Angiotensin-(1-7) on Heart Health in Obese Patients with High Blood Pressure

  This study is testing if a new drug called angiotensin-(1-7) can improve heart health in obese patients with high blood pressure.

  Recruiting Early Phase 1 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06482853

• Eflornithine (DFMO) plus AMXT 1501 for neuroblastoma, CNS tumors, and sarcomas

  This trial tests whether adding the oral drug AMXT 1501 to oral DFMO can help children and young adults (diagnosed by age 21) with relapsed or refractory neuroblastoma, ETMR, ATRT, Ewing sarcoma, osteosarcoma, or newly diagnosed DIPG.

  Recruiting at 14 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 13 other locations · NCT06465199

• Investigating diabetes risk after acute pancreatitis using continuous glucose monitoring

  This study is testing if continuous glucose monitoring can help predict diabetes risk in people who have had acute pancreatitis.

  Recruiting at 13 sites Milton S. Hershey Medical Center · Los Angeles, California and 12 other locations · NCT06401577

• Daily 5-minute resistance training for improving mobility in older adults

  This study is testing if a short daily routine of 5 minutes of resistance training can help older adults move better and walk more easily.

  Recruiting at 2 sites Phase 2/3 Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT06396247

• Restoring low-blood-sugar awareness with closed-loop pumps or targeted education

  This study will test whether using hybrid closed-loop insulin systems or focused education can help adults with type 1 diabetes who no longer notice low blood sugar regain their awareness.

  Recruiting at 8 sites Milton S. Hershey Medical Center · La Jolla, California and 7 other locations · NCT06325202

• Little cigar exposure and oxidative stress markers in adult smokers

  We will test whether using high- or low-oxidant little cigars changes markers of oxidative stress compared with your usual cigarette in adult daily cigarette smokers.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06310187

• Effects of Cognitive Behavioral Therapy and Trazodone on Sleep and Blood Pressure in Insomnia

  This study is testing whether Cognitive Behavioral Therapy and trazodone can improve sleep quality and blood pressure in people with insomnia who either sleep less or have normal sleep duration.

  Recruiting at 4 sites Early Phase 1 Milton S. Hershey Medical Center · Denver, Colorado and 3 other locations · NCT06281756

• Ultrasound-guided placing of an external ventricular drain

  This trial tests whether the SOLOPASS US-guided system can accurately place an external ventricular drain in adults with hydrocephalus.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06253858

• Program to help patients with cirrhosis manage fluid overload after hospital discharge

  This study tests a new program that helps patients with cirrhosis manage swelling from fluid overload after leaving the hospital to see if it can reduce hospital visits and improve their health.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06174272

• A program providing fruit and vegetable prescriptions for diabetes management

  This study is testing whether giving low-income Hispanic adults with Type 2 diabetes vouchers for fruits and vegetables, along with diabetes education, can help them manage their condition better.

  Recruiting Milton S. Hershey Medical Center · Reading, Pennsylvania · NCT06107816

• Exploring the effects of nicotine pouches on daily smokers

  This study is testing whether using a new nicotine pouch can help daily smokers cut down on their cigarette use and improve their health.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT06043362

• A new sweat sensor device for diagnosing cystic fibrosis

  This study is testing a new sweat sensor to see if it can make diagnosing cystic fibrosis easier and more accurate for both patients with the condition and healthy volunteers.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT05998629

• Identifying microRNA biomarkers for infants with opioid withdrawal

  This study is trying to see if certain tiny molecules in the saliva of newborns exposed to opioids can help predict their treatment needs and development outcomes.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT05937594

• Evaluating pain and disability outcomes in patients after limb amputation

  This study is testing different treatments to see how well they help people manage pain after losing a limb.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT05716321

• Treatment for problematic sexual behavior in preteen children

  This study is testing a new treatment for preteen children with problematic sexual behavior to see if it works better than the usual methods.

  Recruiting Milton S. Hershey Medical Center · Harrisburg, Pennsylvania · NCT05514730

• Naxitamab added to standard chemotherapy for high-risk neuroblastoma

  This study is testing if adding a new treatment called naxitamab to regular chemotherapy can help children with high-risk neuroblastoma do better and live longer.

  Recruiting at 25 sites Phase 2 Milton S. Hershey Medical Center · Birmingham, Alabama and 25 other locations · NCT05489887

• Improving diabetes management in hospitals with a decision support tool

  This study is testing a new electronic tool that helps doctors manage blood sugar levels in hospitalized patients with diabetes to see if it improves their care and reduces costs.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT05447806

• How parental emotion regulation affects ADHD treatment outcomes

  This study is testing whether how well parents manage their emotions affects how successful behavior training is for kids aged 5-12 with ADHD and challenging behaviors.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT05299814

• Investigating diabetes after acute pancreatitis

  This study is trying to see if having acute pancreatitis makes people more likely to develop diabetes later on and how that happens.

  Recruiting at 13 sites Milton S. Hershey Medical Center · Los Angeles, California and 12 other locations · NCT05197920

• Collecting data and specimens from pediatric cancer patients

  This study is collecting samples and information from kids with cancer to see how their genes and tumor details can help find better treatments.

  Recruiting at 17 sites Milton S. Hershey Medical Center · Little Rock, Arkansas and 17 other locations · NCT04715178

• Using DFMO for Maintenance Therapy in High Risk Medulloblastoma

  This study is testing if a new oral medication called DFMO can help children and young adults with high-risk medulloblastoma stay cancer-free after their initial treatment.

  Recruiting at 26 sites Phase 2 Milton S. Hershey Medical Center · Little Rock, Arkansas and 25 other locations · NCT04696029

• Comparing liposomal bupivacaine and plain bupivacaine for pain management after thoracoscopic surgery

  This study is testing whether a newer form of bupivacaine can help manage pain after thoracoscopic surgery better and safely compared to the regular version.

  Recruiting Phase 4 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT03737292

• Examining how COX blockade affects blood pressure and vein size

  This study is testing if a pain medication affects blood pressure and vein size in people during a specific blood flow test.

  Recruiting Early Phase 1 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT03513770

• Investigating how leg vein distension affects blood pressure

  This study is testing how swelling in the leg veins affects blood pressure, especially when standing up, to help understand how the body keeps blood pressure steady during changes in position.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT03496792

• Using a combined airway management technique to reduce emergence phenomena after anesthesia

  This study tests a new way of managing airways during anesthesia to see if it can help patients wake up more comfortably after surgery.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT02708836

• Advanced therapy for high-risk neuroblastoma in children

  This study is testing a new combination of treatments for children with high-risk neuroblastoma to see if it helps them do better than the usual therapies.

  Recruiting at 24 sites Phase 2 Milton S. Hershey Medical Center · Birmingham, Alabama and 27 other locations · NCT02559778

• Online training for childcare providers on reporting child abuse

  This study tests an online training program for childcare providers in Pennsylvania to see if it helps them better understand and report suspected child abuse and neglect.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT02225301

Quick answers

How many clinical trials run by Milton S. Hershey Medical Center are recruiting right now?

42, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (42 trials), Canada (5 trials), Australia (1 trial), United Kingdom (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Early Phase 1: 3, Phase 1/2: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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