Using SVC-CI to Predict Fluid Needs in Heart Surgery Patients
Utility of the Superior Vena Cava Collapsibility Index (SVC-CI) to Predict Fluid Responsiveness in Patients With Coronary Artery Disease Undergoing Surgical Revascularization
This study is testing if a new measurement called SVC-CI can help doctors predict how much fluid heart surgery patients will need during their operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Milton S. Hershey Medical Center Academic / other |
| Locations | 1 site (Hershey, Pennsylvania) |
| Trial ID | NCT06645327 on ClinicalTrials.gov |
What this trial studies
This study investigates the superior vena cava collapsibility index (SVC-CI) as a potential marker for predicting fluid responsiveness in patients with coronary artery disease undergoing coronary artery bypass grafting (CABG). Participants will be divided into two groups based on their cardiac output measurements, and the SVC-CI will be assessed using transesophageal echocardiography. An operating room table tilt test will simulate fluid administration to evaluate changes in SVC-CI and cardiac output. The goal is to determine if SVC-CI can effectively guide fluid management during surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with coronary artery disease scheduled for CABG surgery.
Not a fit: Patients undergoing off-pump coronary artery bypass or those with severe cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve fluid management during CABG surgery, potentially leading to better patient outcomes.
How similar studies have performed: While the use of SVC-CI in this context is relatively novel, similar studies have shown promise in using echocardiographic measures to predict fluid responsiveness.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 2. Participants with CAD undergoing CABG utilizing cardiopulmonary bypass 3. Participants who are able to consent for themselves 4. Primary language is English Exclusion Criteria: 1. Age less than 18 years of age 2. Participants with CAD undergoing off-pump coronary artery bypass (OP-CAB) 3. Severe cardiac valvular pathologies or active congestive heart failure 4. Participants in active arrhythmia such as atrial fibrillation and atrial flutter at the time of data collection. 5. Participants who are unable to consent for themselves 6. Primary language is something other than English
Where this trial is running
Hershey, Pennsylvania
- Penn State Hershey Medical Center — Hershey, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Edward Stredny, MD — Milton S. Hershey Medical Center
- Study coordinator: Edward Stredny, MD
- Email: estredny@pennstatehealth.psu.edu
- Phone: 717-531-8521
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.