Using SVC-CI to Predict Fluid Needs in Heart Surgery Patients
Official title: Utility of the Superior Vena Cava Collapsibility Index (SVC-CI) to Predict Fluid Responsiveness in Patients With Coronary Artery Disease Undergoing Surgical Revascularization
Run by Milton S. Hershey Medical Center · NCT06645327 · Data updated 2026-11-12
This study is testing if a new measurement called SVC-CI can help doctors predict how much fluid heart surgery patients will need during their operation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Milton S. Hershey Medical Center Academic / other |
| Locations | 1 site (Hershey, Pennsylvania) |
| Status | Recruiting |
| Started | February 24, 2025 |
| Main results expected | January 2028 |
| Study ends | January 2029 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT06645327 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with coronary artery disease scheduled for CABG surgery.
✕Probably not a fit
Patients undergoing off-pump coronary artery bypass or those with severe cardiac conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the superior vena cava collapsibility index (SVC-CI) as a potential marker for predicting fluid responsiveness in patients with coronary artery disease undergoing coronary artery bypass grafting (CABG). Participants will be divided into two groups based on their cardiac output measurements, and the SVC-CI will be assessed using transesophageal echocardiography. An operating room table tilt test will simulate fluid administration to evaluate changes in SVC-CI and cardiac output. The goal is to determine if SVC-CI can effectively guide fluid management during surgery.
Why it matters
Potential benefit: If successful, this approach could improve fluid management during CABG surgery, potentially leading to better patient outcomes.
How similar studies have gone: While the use of SVC-CI in this context is relatively novel, similar studies have shown promise in using echocardiographic measures to predict fluid responsiveness.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 2. Participants with CAD undergoing CABG utilizing cardiopulmonary bypass 3. Participants who are able to consent for themselves 4. Primary language is English Exclusion Criteria: 1. Age less than 18 years of age 2. Participants with CAD undergoing off-pump coronary artery bypass (OP-CAB) 3. Severe cardiac valvular pathologies or active congestive heart failure 4. Participants in active arrhythmia such as atrial fibrillation and atrial flutter at the time of data collection. 5. Participants who are unable to consent for themselves 6. Primary language is something other than English
Where it's running
-
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Edward Stredny, MD — Milton S. Hershey Medical Center
- Study coordinator: Edward Stredny, MD
- Email: estredny@pennstatehealth.psu.edu
- Phone: 717-531-8521
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
This trial tests whether adding eflornithine (DFMO) as extra or maintenance therapy can improve survival for young people with Ewing sarcoma or osteosarcoma.
-
College student–delivered cognitive behavioral therapy for rural high school students
This project will test whether cognitive-behavioral therapy delivered by trained college students can help high school students in rural Schuylkill County who have symptoms of depression, anxiety, or stress.
-
An AI chatbot to help teens and young adults with eating disorders manage anxiety about weight gain
This project will test an AI-powered chatbot that delivers exposure-based exercises to help adolescents and young adults in a partial hospitalization program reduce anxiety about weight gain.
-
Virtual exposure treatment for adolescents with anorexia nervosa
This project will try virtual exposure therapy to help 14–17-year-olds with anorexia nervosa face and tolerate anxiety about weight gain.
-
CBG/CBD oil for chemotherapy-induced peripheral neuropathy
This will try a CBG/CBD oil to see if it safely reduces pain, numbness, or other nerve symptoms in adults who developed peripheral neuropathy after platinum-based chemotherapy for gastrointestinal cancers.
-
Allogeneic stem cell transplant with low-dose post-transplant cyclophosphamide to prevent graft-versus-host disease.
This study tests whether giving low-dose (25 mg/kg) cyclophosphamide on days +3 and +4 after allogeneic peripheral blood stem cell transplant can prevent GVHD in adults with blood cancers who receive reduced-intensity or non-myeloablative conditioning.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.