Investigating how leg vein distension affects blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to understand the impact of venous distension in the legs on blood pressure, particularly in relation to orthostatic hypertension. The study will utilize various interventions, including limb occlusion and negative pressure, to assess changes in muscle sympathetic nerve activity and mean arterial blood pressure. Participants will be categorized based on their blood pressure responses when standing versus supine, allowing for a detailed examination of the venous distension reflex. The findings could provide insights into the autonomic adjustments necessary for maintaining blood pressure during postural changes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Are capable of giving informed consent
* Are of any race or ethnicity
* Are fluent in written and spoken English
* Whose history and physical exam did not uncover any exclusion criteria
* Are 18 years of age

For subjects with elevated standing BP

* Systolic BP (SBP) during standing is at least 10 mmHg \> the supine SBP
* Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED

For normal subjects without elevated standing BP

* The change in SBP by standing is within ± 5 mmHg from the supine SBP
* Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
* Free of acute or chronic medical conditions

Exclusion Criteria:

* Age \< 18 years of age
* Are a pregnant or nursing woman
* Are a prisoner or institutionalized individual or unable to consent
* Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
* Have orthostatic hypotension or a history of syncope
* Current smoker
* History of blood clots

Where it's running

• Penn State Milton S. Hershey Medical Center
  Hershey, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Jian Cui — Penn State College of Medicine
• Study coordinator: Jian Cui, PhD
• Email: jcui@pennstatehealth.psu.edu
• Phone: 717-531-1799

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.