Examining how COX blockade affects blood pressure and vein size

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the mechanisms of the venous distension reflex (VDR) in humans by examining the effects of COX blockade using ketorolac tromethamine on muscle sympathetic nerve activity (MSNA) and vein size during venous distension. Participants will undergo wrist-to-elbow occlusion and receive either ketorolac or saline in a controlled setting. Measurements will be taken using 3T MRI to assess changes in vein size and MSNA response. Each subject will serve as their own control to enhance the reliability of the results.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Are capable of giving informed consent
* Are any race or ethnicity
* Are fluent in written and spoken English
* Have a satisfactory history and physical exam to meet inclusion/exclusion criteria
* Are free of acute or chronic medical conditions
* Are 21 - 35 years of age (inclusive)
* Weigh over 50 kg

Exclusion Criteria

* Are less than 21 or over 35 years of age
* Are Pregnant or nursing women
* Are prisoners or institutionalized individuals or unable to consent
* Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer).
* Are taking medications that may affect their cardiovascular or nervous system
* Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled)
* Has never taken NSAIDs and therefore would not know if they are allergic to it
* Have a supine BP \>140/90 mmHg
* Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin
* Have history of asthma or nasal polyps
* Have history of GI bleeding or ulcers
* Subjects with ferromagnetic metal implants
* Subjects who are claustrophobic

Where it's running

• Penn State Milton S. Hershey Medical Center
  Hershey, Pennsylvania, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.