Sponsor or institution
Clinical trials and research at Mayo Clinic Arizona
As of November 12, 2026, Find a Trial lists 134 NIH-funded research projects at this institution, with $70.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 134NIH research projects
NIH-funded research (newest 40 of 134)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Predicting Pain Recovery with a Multimodal AI using Harmonized Health Records
Aging patients with headaches will be helped by a new AI tool that uses medical records and brain images from Mayo Clinic and VA to predict who might have persistent pain.
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Understanding immune signals in ALS to guide future therapies
A Mayo Clinic team will study how the immune system sees proteins in the brain of people with ALS and related conditions, to find clues for better treatments.
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Determinants of Pathogenic Anti-PF4 Antibody–Mediated Platelet Activation
This project looks at why certain anti-PF4 antibodies in people cause harmful blood clots and how to better diagnose and treat those cases.
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Understanding how a type of immune cell called ILC2s affect asthma in adults
This grant studies how group 2 innate lymphoid cells influence asthma in adults to help identify new ways to manage airway inflammation.
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EHMT1 Variants and Kleefstra Syndrome: How Structure Shapes Neurodevelopmental Risks
A small NIH grant will explore how genetic changes in EHMT1 affect brain development in Kleefstra Syndrome using computer models and analysis of protein structure.
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Targeting epigenomic regulators to assault pancreatic cancer replication stress
This research tests a new way to treat pancreatic cancer by blocking key epigenetic regulators during DNA replication to make cancer cells less able to cope with replication stress.
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New ideas to understand, diagnose, and treat heparin-induced thrombocytopenia
A Mayo Clinic led study will look at the different kinds of HIT antibodies to improve diagnosis and treatment for people with HIT.
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Comparative care for IBD in Hispanic patients
A Mayo Clinic Arizona team will study how Crohn’s disease and ulcerative colitis progress and respond to treatments in Hispanic patients using real-world data.
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Strengthening teen brain resilience with music during cancer treatment
A pilot program tests whether 10 weeks of online ukulele lessons led by certified music therapists can help teens undergoing radiation therapy maintain cognitive and emotional resilience.
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Career Enhancement for Early-Stage Translational Myeloma Researchers
This grant supports promising young scientists at Mayo Clinic to jumpstart translational myeloma research and develop the skills needed to turn lab findings into practical patient benefits.
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Developmental Research Program for Translational Myeloma Science
A Mayo Clinic program funds early, promising myeloma research with translational potential to move discoveries toward patient care.
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Overcoming resistance to CART cell therapy in multiple myeloma
This grant aims to improve CAR T-cell therapy for people with multiple myeloma by tackling why some patients stop responding, using innovative approaches to boost cancer-fighting cells in the bone marrow.
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Early detection and prevention of multiple myeloma progression
This grant explores non-invasive blood tests to spot when precancerous plasma cell conditions are advancing toward multiple myeloma, with the goal of starting early treatment.
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In vivo CAR-T for myeloma: a new approach to make CAR-T inside patients
A Mayo Clinic Arizona team is testing a one-step therapy that could turn a patient’s own T cells into anti-myeloma CAR-T cells inside the body, aiming to make CAR-T treatment more accessible.
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Biospecimen, Pathology, and Clinical Database Core for Mayo Clinic Myeloma SPORE
A Mayo Clinic research core helps doctors and researchers securely collect, store, and link patient samples and data to advance multiple myeloma research.
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Biostatistics and Bioinformatics Core for Cancer Projects
A Mayo Clinic core gives researchers expert help with statistics, data management, and bioinformatics to support cancer research projects.
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Administrative Core of Mayo Clinic Myeloma SPORE
A patient-focused core that helps organize and fund myeloma research across Mayo Clinic sites to speed up better prevention, detection, and treatment ideas.
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Mayo Clinic Mayo Myeloma SPORE Renewal 2025
A Mayo Clinic research program is renewing a translational effort to advance personalized approaches for multiple myeloma that could benefit patients at Mayo sites and beyond.
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Breaching the tumor’s mechanical barrier to boost immune attack in breast cancer
This NIH grant aims to understand and loosen the physical barriers inside breast tumors so the body's immune system can better attack cancer cells.
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Multimodal AI for Early Pancreatic Cancer Detection
A Mayo Clinic team is building an AI tool that combines CT scans and medical data to identify pancreatic cancer earlier in adults who don’t have symptoms.
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Immunoprevention for multiple myeloma using preclinical models
Researchers will study early-stage multiple myeloma using mouse models to test safe, low-risk prevention strategies for people at high risk of progression.
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Programmed Cell Death 4 and heart protection during doxorubicin treatment
A研究 grant looking at how a heart-protective gene called PDCD4 helps prevent heart damage in children treated with doxorubicin chemotherapy.
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BCMA-directed T cell therapy optimization in multiple myeloma
A Mayo Clinic team is testing improved, immune-based BCMA therapy to help people with multiple myeloma when current treatments fail.
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Flexible NLP toolkit to organize outcomes for breast cancer patients
A Mayo Clinic team is building an adaptable NLP tool to automatically organize and summarize how breast cancer patients are doing over time using their clinic notes and tests.
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AI-powered screening to detect Barrett’s esophagus and early esophageal cancer
A Mayo Clinic team is testing an AI-assisted tool that uses health data to identify people at risk for Barrett’s esophagus and early esophageal cancer so they can get timely endoscopic evaluation.
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Understanding and Treating Gastroparesis: New Registry, Ongoing Studies, and a Possible Targeted Therapy
A Mayo Clinic team is proposing to improve diagnosis and treatment for gastroparesis and related conditions by finishing current studies, creating a larger patient registry, and exploring a potential therapy that targets immune activity in the stomach.
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Dose-LET Volume Histogram to Improve Safe Proton Therapy in Head and Neck Cancer
A Mayo Clinic study will develop a new tool to map dose and LET in spot-scanning proton therapy to reduce severe side effects for head and neck patients.
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Targeting PP4 to boost ovarian cancer response to immunotherapy
A Mayo Clinic study aims to see if inhibiting PP4 can make chemo-resistant ovarian cancer more responsive to immunotherapy.
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Cardiomyocyte signals that help heart cells regrow in large mammals
This grant looks at how non-heart-cell signals from blood vessels and nerves might help heart cells in large animals regrow after injury.
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Liquid embolic material to treat bleeding in tiny blood vessels
A Mayo Clinic team is testing a new injectable liquid material to stop bleeding from very small arteries, using image-guided delivery to create a durable cast and prevent further bleeding.
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How extracellular ATP helps CD8+ T cells live longer to fight infections
A Mayo Clinic study is exploring how a molecule outside cells, extracellular ATP, helps a specific immune cell called CD8+ T cells survive longer to protect against viruses like flu.
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Decoding Valley Fever with AI to understand genomic and clinical clues
A Mayo Clinic team will use an AI approach to study 200 patient-derived Coccidioides isolates to find genomic and clinical patterns that predict how valley fever progresses.
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Rimegepant for Endometriosis Pain in Women 18–45
A Phase II study to see if the CGRP blocker rimegepant can reduce pelvic pain in women with endometriosis who are 18–45 years old.
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TRPS1's role in boosting antitumor immunity by stabilizing regulatory T cells
This NIH grant aims to understand how TRPS1 helps regulatory T cells work in tumors, with the goal of making cancer immunotherapy more effective.
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TAZ and YAP in Brain Cancer: How They Help Glioblastoma Grow and Resist Treatment
A Mayo Clinic team is studying how TAZ and YAP proteins affect DNA repair and treatment resistance in glioblastoma, with the goal of finding new ways to stop tumor growth.
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Engineered, long-lasting cell therapies to treat chronic diseases
Scientists at Mayo Clinic Arizona are creating off-the-shelf, engineered cells that act as tiny, living drug factories to treat diseases like hemophilia, diabetes, and liver disorders, while shielding them from the immune system.
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Image-guided microrobots to prevent vein narrowing in dialysis fistulas
Tiny, soft microrobots will deliver a drug directly to the outflow vein of arteriovenous fistulas used for hemodialysis to try to prevent vein narrowing and clotting in people with end-stage kidney disease.
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Helping the immune system reach and attack breast tumors
Researchers are trying to break down the physical barriers that keep immune cells out of breast tumors so the immune system can better fight the cancer.
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How breathing in allergens leads to allergic immune reactions
This work looks at how inhaled allergens make the immune system produce cells and antibodies that drive asthma, food allergy, and other allergic conditions.
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SIRT7 and insulin-producing beta cells
This project looks at whether SIRT7 helps keep insulin-making beta cells working in people with or at risk for type 2 diabetes.
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