Understanding how a type of immune cell called ILC2s affect asthma in adults
Official title: Roles of group 2 innate lymphoid cells in type 2 immunity and asthma
Funded at Mayo Clinic Arizona · NIH-11552879 · Data updated 2026-11-12
This grant studies how group 2 innate lymphoid cells influence asthma in adults to help identify new ways to manage airway inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | August 18, 2026 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $638,403 |
| NIH project number | 1R56AI192285-01A1 |
| Project ID | NIH-11552879 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with asthma or airway inflammation who could participate in future translational studies or related human research.
✕Less likely to help
People without asthma or airway inflammatory conditions may not directly benefit from this basic immunology research.
What this research studies
The project aims to uncover how lung ILC2s contribute to type 2 immunity in asthma and how they interact with other immune cells. Researchers use mouse models to explore changes in allergen exposure and immune memory, with a focus on lung airways. The findings could reveal new targets to modulate airway inflammation and improve patient outcomes.
Why it matters
Potential benefit: If successful, results could lead to new approaches for preventing or treating asthma by targeting ILC2s and their interactions with other immune cells.
How similar studies have gone: Previous work in animal models has shown context-dependent roles for ILC2s in airway immunity, suggesting potential translational relevance.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Kita, Hirohito — Mayo Clinic Arizona
- Study coordinator: Kita, Hirohito
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.