Early detection and prevention of multiple myeloma progression
Official title: Project 3: Early Detection and Prevention of MM Progression
Funded at Mayo Clinic Arizona · NIH-11421174 · Data updated 2026-11-12
This grant explores non-invasive blood tests to spot when precancerous plasma cell conditions are advancing toward multiple myeloma, with the goal of starting early treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 1, 2015 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $338,496 |
| NIH project number | 2P50CA186781-11 |
| Project ID | NIH-11421174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with MGUS or smoldering multiple myeloma who are being monitored for progression.
✕Less likely to help
Patients not at risk for progression or those not undergoing serial blood monitoring would be unlikely to benefit.
What this research studies
Researchers at Mayo Clinic Arizona plan to use regular blood samples to track changes in MGUS and smoldering myeloma patients. By looking for genomic shifts and immune system clues, they hope to identify who is most likely to progress to multiple myeloma. The project emphasizes non-invasive, serial blood analysis to guide timely interventions before malignant features appear. If successful, this approach could delay or prevent progression and reduce complications. The grant supports a large, long-term effort involving patient participation and serial monitoring.
Why it matters
Potential benefit: If successful, patients at risk could receive earlier, targeted interventions that may delay or prevent progression to active multiple myeloma.
How similar studies have gone: Prior studies show that early intervention in smoldering myeloma can delay progression in some patients, but identifying who benefits most remains challenging.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Bergsagel, Peter Leif — Mayo Clinic Arizona
- Study coordinator: Bergsagel, Peter Leif
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.