Determinants of Pathogenic Anti-PF4 Antibody–Mediated Platelet Activation
Official title: Determinants of Pathogenic Anti-PF4 Antibody-Mediated Platelet Activationathophysiology, diagnosis and treatment
Funded at Mayo Clinic Arizona · NIH-11580959 · Data updated 2026-11-12
This project looks at why certain anti-PF4 antibodies in people cause harmful blood clots and how to better diagnose and treat those cases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | August 1, 2026 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL171911-03 |
| Project ID | NIH-11580959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed anti-PF4 antibody–mediated thrombotic disorders such as HIT, VITT, or MGTS, and clinicians managing these conditions.
✕Less likely to help
People without suspected anti-PF4–mediated thrombosis or who do not require specialized testing may not benefit.
What this research studies
Researchers aim to understand how platelets present PF4 and how specific antibody structures trigger platelet activation, which leads to dangerous clots in conditions like HIT and VITT. The study analyzes how PF4 is displayed on platelets and how antibody glycosylation affects activation, using patient-derived antibodies and glycoengineering. By linking antigen presentation and antibody features to platelet activation, the work seeks to improve frontline tests and guide safer anticoagulant choices. The project will advance knowledge of diagnostic gaps and potential treatment strategies for people with antibody-driven thrombotic disorders.
Why it matters
Potential benefit: If successful, it could improve diagnostic accuracy and lead to better, safer treatment decisions for patients with antibody-mediated clotting disorders.
How similar studies have gone: Prior work shows that specific PF4/antibody interactions and glycosylation patterns influence platelet activation, suggesting this approach is promising but still exploratory.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Kanack, Adam J — Mayo Clinic Arizona
- Study coordinator: Kanack, Adam J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.