Liquid embolic material to treat bleeding in tiny blood vessels
Official title: Liquid embolic material for the treatment of small vessel hemmorhage
Funded at Mayo Clinic Arizona · NIH-11363086 · Data updated 2026-11-12
A Mayo Clinic team is testing a new injectable liquid material to stop bleeding from very small arteries, using image-guided delivery to create a durable cast and prevent further bleeding.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 17, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $711,719 |
| NIH project number | 1R01HL180356-01A1 |
| Project ID | NIH-11363086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute bleeding involving very small vessels (<1 mm) who would benefit from transcatheter embolization.
✕Less likely to help
Patients whose bleeding is not vascular or whose anatomy is unsuitable for catheter-based delivery may not benefit.
What this research studies
This project builds on a prior FDA-approved embolic material to treat acute bleeding, now aiming to control hemorrhage in vessels smaller than 1 mm. Researchers will optimize a biocompatible ionic liquid mixed with PEG and imaging contrast to form a lasting seal in tiny vessels, delivered through catheter guidance. The work focuses on translating a promising material into a safe, effective option for patients with challenging, small-vessel bleeds. If successful, the approach could reduce rebleeding and improve survival for patients who currently have limited treatment options.
Why it matters
Potential benefit: If successful, patients with small-vessel bleeding could experience faster control of bleeding and fewer complications.
How similar studies have gone: Previous work showed feasibility and real-time visualization of the material in small vessels, indicating potential but needing further validation.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Oklu, Rahmi — Mayo Clinic Arizona
- Study coordinator: Oklu, Rahmi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.