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Clinical trials and research at Mario Negri Institute for Pharmacological Research

• 23Clinical trials
• 6Countries

Newest trials

All recruiting trials (23)

• Brain tissue bank for traumatic brain injury patients undergoing contusion removal

  This study collects brain tissue discarded during surgery for contusions in adults with traumatic brain injury to see if molecular changes relate to injury progression and recovery.

  Recruiting at 2 sites Mario Negri Institute for Pharmacological Research · Bergamo and 1 other locations · NCT07683169

• RESOLVIN: Reducing cardiovascular inflammation with fish oil or camelina (plant) oil

  This trial tests whether adding fish oil or camelina (plant) oil to the diet of people over 55 with moderate-to-high cardiovascular risk can lower a lipid-driven inflammation risk score.

  Recruiting at 8 sites Mario Negri Institute for Pharmacological Research · Cortona, Arezzo and 8 other locations · NCT07331103

• Mild TBI in the Emergency Department

  This study tests how often CT scans are needed for adults with mild brain injury in emergency departments and aims to predict short-term outcomes using existing decision rules and new models.

  Recruiting at 20 sites Mario Negri Institute for Pharmacological Research · Novi Ligure, AL and 58 other locations · NCT07021118

• Reproducibility of multiparametric kidney MRI on 1.5T scanners

  This project will test how consistently multiparametric kidney MRI measurements can be obtained on common 1.5T MRI scanners in healthy adults aged 18–70.

  Recruiting Mario Negri Institute for Pharmacological Research · Aarhus and 3 other locations · NCT06884410

• Patiromer to allow more flexible potassium diets and improve quality of life for people on chronic dialysis

  This trial will test whether giving patiromer to people on chronic hemodialysis lets them relax potassium restrictions in their diet without raising their risk of high blood potassium.

  Recruiting Phase 3 Mario Negri Institute for Pharmacological Research · Bergamo, BG · NCT06858280

• See if the ED admission decisions are appropriate

  This study tests whether the decision to admit patients from the emergency department is appropriate for adults who come in with symptoms like chest pain, shortness of breath, fainting, or abdominal pain.

  Recruiting Mario Negri Institute for Pharmacological Research · Alessandria and 6 other locations · NCT06846879

• Advanced ultrasound protocols for arm, kidney, and brain blood vessels

  This will test new advanced ultrasound scans of arm, kidney, and brain blood vessels in adults without prior kidney or brain disease to create reference values and check measurement repeatability.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT06841887

• Repeat chest radiation followed by durvalumab plus ceralasertib for recurring Stage III NSCLC after PACIFIC

  This trial will test whether giving repeat chest radiotherapy followed two weeks later by the immunotherapy durvalumab together with the drug ceralasertib helps people with Stage III non-small cell lung cancer who have a thoracic relapse after the PACIFIC treatment.

  Recruiting at 4 sites Phase 2 Mario Negri Institute for Pharmacological Research · Brescia and 8 other locations · NCT06680050

• How blood flow and sounds relate in arteriovenous fistulas

  This study will test whether MRI and ultrasound recordings of blood flow and the sounds from an AVF can help predict fistula problems in adults with end-stage renal disease who need a new forearm access.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, Bergamo · NCT06411353

• Comparing kidney perfusion methods for transplants

  This study is testing if using a special system to clean kidneys from older or less healthy donors before transplant can help them work better after surgery.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, BG · NCT06374121

• Multipurpose dashboard to monitor emergency department status

  A dashboard is being tested to help people see how crowded nearby emergency departments are and decide where to go, with the aim of reducing unnecessary visits and waiting times.

  Recruiting at 2 sites Mario Negri Institute for Pharmacological Research · Torino and 1 other locations · NCT06372379

• Can we predict which ED patients will need hospitalization and compare centers fairly?

  This observational study tests a predictive model to estimate each patient’s chance of being admitted from the emergency department, to compare hospitals fairly across centers.

  Recruiting at 2 sites Mario Negri Institute for Pharmacological Research · Torino and 1 other locations · NCT06354764

• Anti-nephrin antibodies in people with idiopathic nephrotic syndrome

  This project tests whether adults with idiopathic nephrotic syndrome (including MCD, FSGS, and post-transplant FSGS relapse) have circulating anti-nephrin autoantibodies compared with people with primary membranous nephropathy.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT06334692

• Long-term outcomes in primary membranous nephropathy

  This project will follow adults with primary membranous nephropathy and nephrotic syndrome to see how their disease and real-world treatments affect long-term kidney outcomes.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, BG and 1 other locations · NCT06242327

• Creating a tool to analyze emergency department records using language processing

  This study is testing a new tool that uses language processing to help understand and analyze emergency department records, making it easier for researchers to gather important information from patient visits.

  Recruiting at 2 sites Mario Negri Institute for Pharmacological Research · Milan, Milan and 7 other locations · NCT06240572

• Acetyl-L-carnitine to slow functional decline in ALS

  This trial tests whether two doses of acetyl-L-carnitine can slow loss of independence in adults with recent-onset ALS.

  Recruiting at 14 sites Phase 2/3 Mario Negri Institute for Pharmacological Research · Sydney, Australia and 18 other locations · NCT06126315

• Using RNA sequencing to diagnose rare genetic diseases

  This study is testing if a new RNA sequencing method can help find the genetic causes of rare diseases in people who haven't been diagnosed after other tests.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT05996731

• Understanding rare gene mutations in atypical hemolytic uremic syndrome for personalized therapy

  This study is testing how rare gene mutations in people with atypical hemolytic uremic syndrome can help doctors create personalized treatments to improve their health.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT05805202

• Analysis of sounds from vascular access in dialysis patients

  This study is testing whether listening to the sounds from different types of vascular access can help doctors understand how well they work for patients on dialysis.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, BG · NCT05612022

• Using Argon for Ventilation After Cardiac Arrest

  This study is testing if using argon gas mixed with oxygen can help protect the brain and heart in people who have just been resuscitated after a cardiac arrest.

  Recruiting at 7 sites Phase 2 Mario Negri Institute for Pharmacological Research · Genova, GE and 8 other locations · NCT05482945

• Identifying Prognostic Factors and Quality of Care in Severe Brain Injuries

  This study is trying to find out what factors can help predict recovery for people with severe brain injuries and how these factors affect their rehabilitation progress.

  Recruiting at 20 sites Mario Negri Institute for Pharmacological Research · Alessandria and 26 other locations · NCT04905264

• Evaluating healthcare quality in semi-intensive care units

  This study is trying to see how well semi-intensive care units are providing care by collecting data from patients and hospitals over five years.

  Recruiting at 14 sites Mario Negri Institute for Pharmacological Research · Milan, Milan and 17 other locations · NCT04676347

• Investigating B Cells in Membranous Nephropathy

  This study looks at how certain immune cells called B-cells affect whether patients with membranous nephropathy respond to a specific treatment that targets these cells.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT04095156

Quick answers

How many clinical trials run by Mario Negri Institute for Pharmacological Research are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Italy (23 trials), Switzerland (2 trials), Australia (1 trial), Denmark (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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