Using Argon for Ventilation After Cardiac Arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the use of argon gas as a ventilation mixture for patients who have been resuscitated from out-of-hospital cardiac arrest. It is a multicenter, randomized, controlled, single-blinded study focusing on safety assessments in a critical patient population. Eligible patients will receive argon in combination with oxygen within four hours of regaining spontaneous circulation, and outcomes will be monitored for six months. The study aims to determine if argon can reduce neurological and myocardial damage following cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm;
* age ≥ 18 years;
* unconsciousness after return of spontaneous circulation (ROSC);
* duration of CPR ≤ 40 mins;
* initiation of study intervention ≤ 4 hrs from ROSC;
* stable SaO2 ≥ 94% with a FiO2 of 30%.

Exclusion Criteria:

* Non-witnessed CA;
* CA of traumatic origin or from a non-presumably cardiac cause;
* CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole);
* female of childbearing potential defined as younger of 50 years;
* pregnancy;
* known terminal illness;
* pre-CA cerebral performance category (CPC) ≥ 3;
* initiation of the study intervention \> 4 hrs from ROSC;
* participation to another clinical trial

Where it's running

• Ospedale Policlinico San Martino di Genova
  Genova, Ge, Italy Recruiting
• Ospedale San Gerado
  Monza, Mb, Italy Recruiting
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  Milan, Milan, Italy Recruiting
• Ospedale Civile Santa Maria degli Angeli di Pordenone
  Pordenone, Pordenone, Italy Recruiting
• Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  Roma, Rm, Italy Recruiting
• Ospedale Santa Chiara di Trento
  Trento, Trento, Italy Recruiting

Study contacts

• Principal investigator: Giuseppe Ristagno, MD, PhD — Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
• Study coordinator: Giulia Merigo, MSc
• Email: giulia.merigo@unimi.it
• Phone: +39 0250320463

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.