Mild TBI in the Emergency Department

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes CT use for adults with mild traumatic brain injury presenting to Italian emergency departments. It evaluates existing decision rules (e.g., Canadian CT Head Rule, Nexus II, New Orleans criteria, NICE guidelines) and aims to validate these tools while developing a model to predict medium-term outcomes. The project seeks to understand practice variability, reduce unnecessary radiation exposure, and inform more efficient patient management in the ED. It will enroll adult ED patients with mild TBI (Glasgow Coma Scale 13-15), excluding those under 18 or with prolonged loss of consciousness or amnesia. Lead coordination is by the Mario Negri Institute, with sites in Novi Ligure, Chiari, and Bagno a Ripoli.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adult patients arriving in the emergency department. Adult patients with mild TBI Adult patients with Glasgow Coma Scale 13-15.

Exclusion Criteria:

All patients under 18 years. Patients with trauma-associated loss of consciousness lasting more than 30 minutes.

Patients with post-traumatic amnesia lasting more than 24 hours.

Where it's running

• Presidio Ospedaliero S'Antonio Abate
  Tolmezzo, Ud, Italy Recruiting
• Ospedale Città del Piave
  San Donà di Piave, Ve, Italy Recruiting
• San Donato
  Arezzo, Italy Recruiting
• Spedali Civili
  Brescia, Italy Recruiting
• Ospedale Unico della Versilia
  Camaiore, Italy Recruiting
• Ospedale Cardarelli
  Campobasso, Italy Recruiting

+9 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Giovanni Nattino
• Email: giovanni.nattino@marionegri.it
• Phone: +39 0354535351

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Brain tissue bank for traumatic brain injury patients undergoing contusion removal

  This study collects brain tissue discarded during surgery for contusions in adults with traumatic brain injury to see if molecular changes relate to injury progression and recovery.

  Recruiting at 2 sites Mario Negri Institute for Pharmacological Research · Bergamo and 1 other locations · NCT07683169

• RESOLVIN: Reducing cardiovascular inflammation with fish oil or camelina (plant) oil

  This trial tests whether adding fish oil or camelina (plant) oil to the diet of people over 55 with moderate-to-high cardiovascular risk can lower a lipid-driven inflammation risk score.

  Recruiting at 8 sites Mario Negri Institute for Pharmacological Research · Cortona, Arezzo and 8 other locations · NCT07331103

• Reproducibility of multiparametric kidney MRI on 1.5T scanners

  This project will test how consistently multiparametric kidney MRI measurements can be obtained on common 1.5T MRI scanners in healthy adults aged 18–70.

  Recruiting Mario Negri Institute for Pharmacological Research · Aarhus and 3 other locations · NCT06884410

• Patiromer to allow more flexible potassium diets and improve quality of life for people on chronic dialysis

  This trial will test whether giving patiromer to people on chronic hemodialysis lets them relax potassium restrictions in their diet without raising their risk of high blood potassium.

  Recruiting Phase 3 Mario Negri Institute for Pharmacological Research · Bergamo, BG · NCT06858280

• See if the ED admission decisions are appropriate

  This study tests whether the decision to admit patients from the emergency department is appropriate for adults who come in with symptoms like chest pain, shortness of breath, fainting, or abdominal pain.

  Recruiting Mario Negri Institute for Pharmacological Research · Alessandria and 6 other locations · NCT06846879

• Advanced ultrasound protocols for arm, kidney, and brain blood vessels

  This will test new advanced ultrasound scans of arm, kidney, and brain blood vessels in adults without prior kidney or brain disease to create reference values and check measurement repeatability.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT06841887

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.