Sponsor or institution
Clinical trials and research at J. David Gladstone Institutes
As of November 12, 2026, Find a Trial lists 115 NIH-funded research projects at this institution, with $107.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 115NIH research projects
NIH-funded research (newest 40 of 115)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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HOPE: a new approach to silencing HIV and preventing rebound
A large NIH grant is testing a combination strategy to turn off HIV genes in people on treatment so the virus stays gone and health improves.
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Undo HIV: Understanding and targeting the active HIV reservoir
Aims to map and ultimately eliminate the HIV cells that stay active despite therapy to improve long-term control of HIV in people living with HIV.
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TREM2 and TYROBP in Alzheimer's brain network changes
This grant looks at how microglial proteins TREM2 and TYROBP influence brain network excitability in people with Alzheimer's disease and related dementias.
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Commensal respiratory viruses and how they interact with the human airway
A small NIH grant is exploring how the normal viruses living in our airways interact with our cells to stay harmless and support healthy breathing.
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Targeted delivery systems to edit blood stem cells
Aims to safely deliver genome-editing tools to blood stem cells to treat diseases like acute myeloid leukemia.
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Regionally Specific Transplants to Restore Breathing After Cervical Spine Injury
A patient-focused look at a study that aims to repair breathing circuits after cervical spinal cord injury using stem-cell–derived nerve cells and targeted neuromodulation.
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Machine learning to understand how noncoding DNA variants affect heart development
A new AI-based tool is being developed to predict how noncoding genetic changes influence heart development and contribute to congenital heart disease in children.
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Roche Discovery Ultra supports automated tissue analysis at Gladstone to boost brain disease and cancer research
A core lab at Gladstone is acquiring a Roche Discovery Ultra instrument to automate tissue staining and imaging, helping researchers study Alzheimer’s disease and cancer more efficiently.
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Methods to build and annotate tissue maps from spatial genomic data
Aims to create detailed 3D tissue maps from 2D spatial data to help understand how cells organize in healthy and diseased tissues.
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Chromatin control of immune cells after a heart attack
Researchers are studying how certain heart-attack–related immune cells are regulated at the genetic level to find ways to reduce harmful inflammation and improve healing.
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Epigenetic clues to stop heart scarring and failure
A patient-focused look at how turning off specific epigenetic signals may reduce heart scarring and improve heart function in people with heart failure.
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Understanding why too much oxygen hurts the body and how to protect it
This grant looks at why excess oxygen damages the lungs, brain, and other tissues and explores ways to block that damage to improve outcomes for people with acute lung injuries.
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OPC-X screen: discovering compounds to help remyelination in MS
A research grant is testing small molecules that could help brain cells responsible for making myelin to mature and remyelinate nerves in people with multiple sclerosis.
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Understanding Lewy Body Dementias to Improve Care
Researchers are exploring what makes Lewy body dementias unique so that patients may receive better, more targeted treatments in the future.
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Revitalized vitamin biology framework with new sensors and precision therapies
A research project aims to map how vitamins work in the body and to develop targeted vitamin-based treatments that could help people with specific genetic or metabolic conditions.
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Sorting and Sequencing Latent HIV Reservoirs in Opioid-Using People
This grant tests whether HIV-infected cells in people who use opioids have unique molecular signatures that could reveal how the virus hides and persists.
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Decoding early heart development to help congenital heart defects
Researchers study how early heart-determining transcription factors shape heart formation to better understand congenital heart defects in children.
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ApoE4 and Alzheimer's Disease: Why Some People Stay Healthy
A research grant is studying why people with the apoE4 gene develop Alzheimer’s sooner or stay healthy, with the goal of finding new ways to prevent or treat the disease.
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NAXD deficiency: how vitamin B3 could help
A study in mice and related experiments tests whether vitamin B3-based approaches can prevent problems caused by NAXD deficiency and improve organ function.
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Computational prediction of gut enzymes that modify cancer drugs
A new computerized platform will predict which gut bacteria could change anti-cancer drugs, helping tailor safer and more effective treatments for patients.
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Understanding tiny brain vessels and memory loss at single-cell detail
Aims to map human brain blood vessel cells at the single-cell level to understand how small-vessel disease contributes to dementia in people with Alzheimer’s.
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Role of acetylation in HIV transcription regulation
Researchers are studying how specific protein modifications (acetylation) control HIV latency and reactivation, with the goal of guiding new ways to achieve a functional cure.
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TREM2 antibodies and brain network health in Alzheimer's disease
A study to see if special antibodies for TREM2 can calm brain hyperactivity and cognitive problems in people with Alzheimer’s disease, by altering immune and neural signals.
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Cardiogenesis: Molecular Clues to Heart Birth Defects
This grant studies why congenital heart defects happen by examining how heart cells form and how genes like those on chromosome 21 influence this process in early development.
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AD connectivity maps from patient-derived brain cells to help find quicker treatments
A research project uses stem cell-derived brain cells from people with Alzheimer's to map how their brain connections form, aiming to spot new ways to treat the disease.
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Locking HIV into a silent state to prevent reactivation
Researchers aim to develop drugs that keep HIV permanently silent to help people living with HIV, especially those who also have substance use disorders.
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Finding and targeting hidden HIV in the gut
This work looks for hidden HIV in the gut of people living with HIV who have undetectable viral loads and tries drug combinations on their cells to wake and help remove infected cells.
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Small molecule therapy for calcific aortic valve disease
A new drug candidate is being studied to slow or stop calcification of the aortic valve in adults with valve disease.
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Blocking active HIV reservoirs to reduce inflammation in older adults
This project will try to lower chronic inflammation in people with HIV aged 65 and older by targeting infected cells that still produce viral genes despite antiretroviral therapy.
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Understanding rare genetic clues to Alzheimer’s risk
A research project aims to find how rare noncoding genetic changes contribute to Alzheimer's risk and why they may lead to brain degeneration.
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Why some people with APOE4 develop Alzheimer's while others stay healthy
This work looks at how the APOE4 gene changes brain activity and biology in ways that raise Alzheimer's risk and why some people with APOE4 remain symptom-free.
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Rapid tests to type Klebsiella capsules and design targeted phage treatments
A project to quickly identify Klebsiella capsule types and design precise phage cocktails to treat infections, using high-throughput tests.
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High-throughput tests to compare how natural and engineered receptor binding proteins work against bacteria
A streamlined set of rapid sequencing-based tests will measure different steps of phage infection to help develop personalized phage therapies for troublesome bacteria.
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Organoid and Human Cell Culture Core for Phage Therapy against antibiotic-resistant bacteria
A core facility at a leading research center is developing advanced human-based models to test phage therapies against resistant bacteria, with a focus on Klebsiella pneumoniae.
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Advanced Computational Core supports smarter phage therapy design
A research center will use AI and high-throughput tests to design phage therapies against multi-drug resistant bacteria like Klebsiella pneumoniae, aiming to speed up precise matching of phages to bacterial strains.
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Administrative Core to Lead Phage Therapy Center
The Administrative Core coordinates leadership, compliance, and data sharing for a center focused on phage therapy to fight antibiotic-resistant infections.
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AI-guided phage design to fight drug-resistant infections
A research center will develop AI-guided phage therapies and fast tests to fight drug-resistant Klebsiella pneumoniae and other bacteria.
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Genetic changes that raise risk for pesticide-linked Parkinson's
This project looks at whether certain gene changes make agricultural workers more likely to develop Parkinson's disease after pesticide exposure.
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Reprogramming T cells to boost their cancer-fighting power
Researchers are designing engineered T cells with added genes to help them stay active longer and better attack cancers that don't respond to current cell therapies.
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NOX2, oxidative stress, and overactive brain networks in Alzheimer's
Researchers are looking into whether a molecule called NOX2 causes oxidative stress, reduced brain glucose use, and overactive brain networks that may speed memory loss in people with Alzheimer's.
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