Roche Discovery Ultra supports automated tissue analysis at Gladstone to boost brain disease and cancer research
Official title: Roche Discovery Ultra
Funded at J. David Gladstone Institutes · NIH-11421807 · Data updated 2026-11-12
A core lab at Gladstone is acquiring a Roche Discovery Ultra instrument to automate tissue staining and imaging, helping researchers study Alzheimer’s disease and cancer more efficiently.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $175,000 |
| NIH project number | 1S15OD042572-01 |
| Project ID | NIH-11421807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians affiliated with Gladstone, UCSF Mission Bay, and Bay Area biotech partners who utilize tissue-based pathology services.
✕Less likely to help
Direct patient participation is not part of this grant; benefits accrue to researchers through better services.
What this research studies
The Histology and Light Microscopy Core at Gladstone wants to replace manual, time-consuming staining with automated immunohistochemistry and in situ hybridization. The new platform will enable consistent, high-throughput analysis of protein and RNA in tissue samples, with both brightfield and fluorescence imaging. This will expand available services, improve workflow efficiency, and enhance data quality for researchers in the Bay Area, including UCSF collaborators and biotech partners. The upgrade aims to support better visualization of disease-related targets in brain and cancer tissues, contributing to more reliable research outputs. This is a facility enhancement that could indirectly accelerate studies related to Alzheimer’s disease and related conditions as well as cancers.
Why it matters
Potential benefit: Improved accuracy and speed of tissue-based analyses could accelerate discoveries in Alzheimer’s disease and cancer research.
How similar studies have gone: Hospitals and research centers have successfully implemented automated histology platforms to improve consistency and throughput.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Srivastava, Jane — J. David Gladstone Institutes
- Study coordinator: Srivastava, Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.