Blocking active HIV reservoirs to reduce inflammation in older adults
Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV
This project will try to lower chronic inflammation in people with HIV aged 65 and older by targeting infected cells that still produce viral genes despite antiretroviral therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11320733 on NIH RePORTER |
What this research studies
You may be asked to provide samples and clinical information if you are a person living with HIV, especially if you are 65 or older. The team will use a new single-cell sequencing method called HIV-Seq to find and describe HIV-infected cells that remain transcriptionally active even on ART, and compare their features between men and women. They will include people with fully suppressed virus and those with non-suppressible viremia to understand extremes of viral activity, and measure links between those cells and markers of chronic inflammation. Laboratory experiments will test ways to block ongoing viral gene expression in those cells to identify potential targets for future therapies.
Who could benefit from this research
Good fit: Ideal candidates are people living with HIV who are aged 65 or older, including those on suppressive ART and those with persistent detectable viremia.
Not a fit: This project may not directly benefit younger people with HIV, people without HIV, or those unable to visit participating clinical sites.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that lower chronic inflammation and reduce age-related complications for older people living with HIV.
How similar studies have performed: Related efforts to target HIV reservoirs and reduce inflammation have shown promise in laboratory and early clinical work, but focusing on transcriptionally-active reservoirs in older adults is relatively new.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Roan, Nadia R — J. David Gladstone Institutes
- Study coordinator: Roan, Nadia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.