Methods to build and annotate tissue maps from spatial genomic data
Official title: Methods to build and annotate tissue atlases using spatial genomic data
Funded at J. David Gladstone Institutes · NIH-11418363 · Data updated 2026-11-12
Aims to create detailed 3D tissue maps from 2D spatial data to help understand how cells organize in healthy and diseased tissues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 5, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $829,659 |
| NIH project number | 5R01HG013736-03 |
| Project ID | NIH-11418363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a direct patient enrollment study; the project focuses on atlas construction using tissue data.
✕Less likely to help
No immediate patient participation or direct treatment impact.
What this research studies
This project will develop new methods to turn 2D spatial genomic data into annotated 3D tissue atlases that can be queried for specific coordinates or regions. It will address challenges like small field-of-view, normalization, and cross-sample alignment to integrate spatial data with single-cell data. The resulting atlases will help researchers study how local cell environments influence cell states in adult human tissues, including the brain. The work will use technologies such as MERFISH, Slide-seqV2, MIBI, and histology images to build and annotate the 3D maps.
Why it matters
Potential benefit: If successful, patients may benefit from improved understanding of tissue organization and disease biology that could inform future diagnostics or therapies.
How similar studies have gone: Other spatial genomics efforts have shown that spatial context improves understanding of tissue organization and disease.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Engelhardt, Barbara — J. David Gladstone Institutes
- Study coordinator: Engelhardt, Barbara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.