Revitalized vitamin biology framework with new sensors and precision therapies
Official title: A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies
Funded at J. David Gladstone Institutes · NIH-11392334 · Data updated 2026-11-12
A research project aims to map how vitamins work in the body and to develop targeted vitamin-based treatments that could help people with specific genetic or metabolic conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 14, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,321,208 |
| NIH project number | 5R01AT013724-02 |
| Project ID | NIH-11392334 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with vitamin-related metabolic or genetic conditions or those who could benefit from personalized vitamin therapies may be eligible in future translational steps.
✕Less likely to help
Individuals without vitamin-related disorders or those unlikely to respond to vitamin-based interventions may see limited direct benefit.
What this research studies
This project plans to use modern techniques to identify enzymes and pathways that depend on vitamin cofactors, and to uncover how the body senses vitamin levels and signals accordingly. It will employ methods like thermal stability proteomics, gradient metabolomics, genome-wide CRISPR screens, and detailed mouse model phenotyping to find where vitamins matter most. The goal is to translate these findings into new, targeted approaches for vitamin-related diseases and personalized therapies. By exploring megavitamin strategies in certain genetic disorders, the study hopes to identify situations where high-dose vitamins could be beneficial.
Why it matters
Potential benefit: If successful, the work could lead to more effective and safer vitamin-based therapies tailored to individual patients' genetic and metabolic profiles.
How similar studies have gone: Preliminary work with vitamin B3 showing lifespan extension in a genetic disorder suggests potential for vitamin-based interventions, but broader approval awaits further validation.
Where this research is happening
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J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Jain, Isha Himani — J. David Gladstone Institutes
- Study coordinator: Jain, Isha Himani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.