Cardiogenesis: Molecular Clues to Heart Birth Defects
Official title: Cardiogenesis: Molecular Mechanisms
Funded at J. David Gladstone Institutes · NIH-11335623 · Data updated 2026-11-12
This grant studies why congenital heart defects happen by examining how heart cells form and how genes like those on chromosome 21 influence this process in early development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 10, 1997 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $787,185 |
| NIH project number | 5R01HL057181-31 |
| Project ID | NIH-11335623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with congenital heart defects, especially those related to valvuloseptal development and Down syndrome, may benefit from future implications of this research.
✕Less likely to help
There may be no direct benefit to current participants since the study is laboratory and animal-model based.
What this research studies
Researchers will map how individual heart cells develop and what genetic changes push them toward defects, using advanced single-cell transcriptional and epigenetic profiling. The work focuses on valvuloseptal defects, common in congenital heart disease, and aims to link specific genes to disrupted heart structure. Insights could point to why children with Down syndrome have heart defects and which genes drive them. The project builds on a mouse model to test which duplicated genes cause problems in heart cell formation.
Why it matters
Potential benefit: Better understanding of the genetic causes of congenital heart defects could lead to earlier diagnosis and new routes for prevention or treatment.
How similar studies have gone: Previous studies using single-cell analysis have revealed key developmental cell types and gene changes, supporting a path toward identifying disease-causing genes.
Where this research is happening
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J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Srivastava, Deepak — J. David Gladstone Institutes
- Study coordinator: Srivastava, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.