Sponsor or institution
Clinical trials and research at East Tennessee State University
As of November 12, 2026, Find a Trial lists 1 clinical trial run by East Tennessee State University that is recruiting, in United States. There are also 44 NIH-funded research projects at this institution, with $16.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1Clinical trials
- 44NIH research projects
- 1Country
All recruiting trials (1)
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Independent walking program with or without walking poles for people with Parkinson disease
This study will test whether an 8-week independent walking program using walking poles helps people with Parkinson disease improve their walking compared with walking without poles.
NIH-funded research (newest 40 of 44)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Engineering exosome-based CRISPR therapies to clear HBV infection
A patient-facing look at a hopeful new approach that uses engineered exosomes to deliver CRISPR-based therapies aimed at eliminating HBV from infected cells.
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Targeted CRISPR Cas12a Delivery to HIV-infected Cells
A study to test a new way to delete HIV from infected immune cells using a specialized CRISPR tool delivered by tiny lipid particles.
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Keap1-NRF2 pathway and EBV: how a cellular defense system helps the virus persist
A study at East Tennessee State University will look at how EBV may hijack a key cellular defense pathway to support virus survival and disease, with potential implications for treating EBV-related illnesses.
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Targeting how macrophages stick to damaged arteries in atherosclerosis
This grant explores how inflammatory fats create sticky spots in artery walls that trap macrophages, which could worsen atherosclerosis.
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Targeting death receptors to boost MET-CAR T cells for glioblastoma
Aims to make MET-CAR T cells work better against glioblastoma by using radiation to trigger death receptors on tumor cells.
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Characterizing how acetaldehyde-modified proteins relate to alcohol-related liver disease
This grant looks at how acetaldehyde, a byproduct of alcohol, changes proteins in the liver to better understand why alcohol-related liver disease develops.
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Neutrophil Swarming to Fungal Invaders in Diabetes
Researchers are studying how a frontline immune cell, neutrophils, swarm around fungal invaders and how this behavior may be weaker in people with diabetes.
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Nucleus reuniens in the thalamus as a way to support memory in people with Alzheimer’s disease
This NIH grant supports research on how a specific brain region (nucleus reuniens) helps the memory network work together, with potential relevance for people affected by Alzheimer’s disease and dementia.
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Investigating anti-inflammatory treatments for people with polysubstance use disorders
Aiming to better understand how inflammation in the brain is involved when people misuse fentanyl and methamphetamine, to guide future therapies.
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How brain hypocretin signals change when methamphetamine and fentanyl are used together
Looks at whether blocking a brain chemical called hypocretin might reduce methamphetamine and fentanyl use in people who use both drugs.
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Vibratome instrument upgrade to study brain disorders
A new vibratome instrument will be bought to help researchers prepare high-quality brain slices from CNS disease models for detailed cellular and molecular studies.
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Lactate's effect on B cells in sepsis and immune paralysis
This grant explores how lactate affects B cells during sepsis to explain why the immune system slows down after infection.
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LC-MS/MS instrument to power biomedical research and education
A new liquid chromatography–tandem mass spectrometry (LC-MS/MS) instrument will support biomedical research and hands-on training for ETSU students and researchers across medicine, pharmacy, public health, and more.
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Improving smell recovery by targeting FAK and CNTF signals
A human-focused grant hoping to boost the body’s own ability to regenerate our sense of smell after injury or aging by influencing specific cellular signals.
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Afferent Pathways Behind Vagus Nerve Therapy
This grant studies how activating the vagus nerve affects brain circuits to improve outcomes in central nervous system conditions.
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How special liver cells and a protective protein affect severe infection and liver function
This project looks at how a protective protein in the liver's lining cells helps the liver fight bacterial infection and manage metabolism during sepsis.
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Exosome delivery of CRISPR/Cas9 to target hepatitis B in liver cells
Testing a non-viral exosome delivery of CRISPR/Cas9 to remove hepatitis B virus DNA from infected liver cells.
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How aging affects the retinal cells that support central vision
This work looks at whether falling levels of histone proteins in retinal pigment epithelium (RPE) cells contribute to age-related macular degeneration in older adults.
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Lactate and immune recovery after sepsis
This project looks at whether high lactate levels after sepsis make immune cells age and stop working, increasing the chance of new infections.
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Treating brain inflammation in people who use both opioids and stimulants
Seeing whether reducing brain inflammation could help people who use both fentanyl and methamphetamine.
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A new method to target and eliminate hepatitis B virus DNA using CRISPR technology
This study is testing a new way to use CRISPR technology to safely and effectively remove the hepatitis B virus from people who are infected, aiming to provide a better treatment option than what’s currently available.
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Investigating how vagal nerve stimulation can improve heart failure treatment
This study is looking into how vagal nerve stimulation (VNS) therapy can help improve heart failure by figuring out how it activates certain brain cells, with the goal of finding better ways to treat heart failure for patients like you.
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Targeting a thalamic hub to restore memory and sleep brain rhythms
Trying to restore memory-supporting brain rhythms by stimulating a small thalamic hub that may be disrupted in Alzheimer's disease.
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A new method to boost the body's immune response against infections
This study is looking at how we can help your immune system remember and fight infections better by using a natural substance from fungi called β-glucans, with the hope of creating new treatments that offer longer-lasting protection against illnesses.
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Acquisition of a new ultrasound imaging system for advanced cardiovascular and cancer research
This study is all about getting a new, high-tech ultrasound machine to help doctors and researchers at East Tennessee State University take better pictures of the heart and cancer, making it easier to track health changes over time.
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Investigating a new regulator that controls a system used by bacteria to infect cells
This study is looking at a new part of a germ called Pseudomonas aeruginosa that helps it cause infections, with the goal of finding new ways to treat these tough infections and help patients who are struggling with antibiotic resistance.
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Helping the Sense of Smell Recover After Injury or Illness
This project looks for new ways to help people regain their sense of smell when it's lost due to injury, infection, or aging.
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Using engineered exosomes to target and eliminate HBV-infected cells
This study is exploring a new way to help people with chronic hepatitis B by using specially designed tiny particles that can deliver tools to directly target and remove the virus from infected liver cells, aiming to provide a safer and more effective treatment than what’s currently available.
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Understanding how liver cells affect immune and metabolic functions during sepsis
This study is looking at how certain liver cells help the body fight infections during sepsis and how a specific protein called HSPA12B affects their function, which could lead to better treatments for people dealing with liver problems caused by sepsis.
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Investigating how aging affects histone expression in the retinal pigment epithelium.
This study is looking at how aging affects certain proteins in the eye that might play a role in age-related macular degeneration (AMD), which can lead to vision loss, and it hopes to find ways to help protect eye health as we get older.
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Developing new therapies to eliminate chronic hepatitis B virus infection
This study is exploring a new way to help people with chronic hepatitis B by using special tiny particles to deliver a gene-editing tool that could completely get rid of the virus, offering hope for a cure instead of just managing the infection.
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Investigating how lactate affects immune function in sepsis
This study is looking at how high levels of lactate in the body might affect the immune system of people who survive sepsis, with the goal of finding ways to help them stay healthier and reduce the risk of future infections.
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Creating a vaccine to protect against the dangerous fungus Candida auris.
This study is working on a new vaccine to help protect people from Candida auris, a tough fungus that can cause serious infections, by using a part of the fungus to boost the immune system and keep you safe.
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Understanding how aging affects heart health through cell changes
This study is looking at how getting older affects heart health by checking out why certain cells in our blood vessels stop working properly, and it’s especially for older adults who want to understand how to keep their hearts healthier as they age.
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Understanding how immune cells respond to fungal infections
This study is looking at how immune cells called neutrophils work together to fight off fungal infections like Candida albicans, using a special device to see how they move and interact with the fungi, which could help us find better ways to boost our immune response when we're sick.
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Investigating how aging affects immune cells in HIV patients who don't respond to treatment
This study is looking at why some older HIV patients have trouble with their immune cells and age faster, hoping to find ways to help them feel better and improve their health.
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Improving recovery support for opioid use disorder in Central Appalachia
This study is all about helping people in Central Appalachia who are dealing with opioid use disorder by creating a better support system that connects them with local resources and treatment centers, so they can have a better chance at staying in treatment and achieving lasting recovery.
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Investigating how C-reactive protein helps fight pneumococcal infections
This study is looking at how a protein called C-reactive protein helps your immune system fight off infections from a common bacteria, and it aims to find out how this protein works early on and why it might not be as helpful later, which could lead to better treatments for infections.
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Understanding how sex differences affect fear extinction in PTSD
This study is looking at how fear can be unlearned in people with PTSD, especially why women might react differently than men to treatments, by using animal models to explore a specific brain factor that could help improve therapy for everyone.
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Investigating how lactate affects heart function during sepsis
This study is looking at how high levels of lactate, a substance that can build up during severe infections like sepsis, might hurt heart and blood vessel function, and it aims to find ways to lower lactate to help improve heart health and survival for patients dealing with sepsis.
Quick answers
How many clinical trials run by East Tennessee State University are recruiting right now?
1, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.