Investigating how aging affects immune cells in HIV patients who don't respond to treatment
Mitochondrial Dysfunction in Aging CD4 T cells in HIV-immune Non-responders.
This study is looking at why some older HIV patients have trouble with their immune cells and age faster, hoping to find ways to help them feel better and improve their health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Tennessee State University NIH-funded |
| Lab location | 1 site (Johnson City, United States) |
| Project ID | NIH-10845843 on NIH RePORTER |
What this research studies
This research focuses on understanding the mitochondrial dysfunction and premature aging of CD4 T cells in older HIV patients who do not respond well to antiretroviral therapy. The study aims to uncover the molecular mechanisms behind these changes, which may contribute to ongoing health issues in these patients. By analyzing the cellular processes involved, researchers hope to identify potential targets for improving immune function and overall health in this population. The approach includes examining mitochondrial respiration, ATP production, and markers of aging in these immune cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults living with HIV who are classified as immune non-responders despite receiving antiretroviral therapy.
Not a fit: Patients who are younger or those who have a robust immune response to HIV treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance immune function and reduce health complications for older HIV patients.
How similar studies have performed: While the specific focus on mitochondrial dysfunction in aging CD4 T cells in HIV non-responders is relatively novel, related research has shown promising results in understanding immune aging and dysfunction.
Where this research is happening
Johnson City, United States
- East Tennessee State University — Johnson City, United States (Active)
Researchers
- Principal investigator: Yao, Zhi Q. — East Tennessee State University
- Study coordinator: Yao, Zhi Q.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.