Investigating how aging affects histone expression in the retinal pigment epithelium.
Histone Expression in the Aging RPE
['FUNDING_R01'] · EAST TENNESSEE STATE UNIVERSITY · NIH-11050490
This study is looking at how aging affects certain proteins in the eye that might play a role in age-related macular degeneration (AMD), which can lead to vision loss, and it hopes to find ways to help protect eye health as we get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST TENNESSEE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (JOHNSON CITY, UNITED STATES) |
| Trial ID | NIH-11050490 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the changes in histone expression that occur in the retinal pigment epithelium (RPE) as people age. The study aims to explore whether the loss of histone expression impacts gene activity, leads to cell death, or contributes to age-related macular degeneration (AMD), a condition that can cause vision loss. By examining the molecular mechanisms involved, the research seeks to identify potential targets for therapeutic intervention to preserve RPE function and prevent AMD progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or experiencing early signs of age-related macular degeneration.
Not a fit: Patients with non-age-related vision issues or those who do not have any retinal pigment epithelium concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or slow down age-related macular degeneration, potentially preserving vision for many individuals.
How similar studies have performed: While the specific focus on histone expression in aging RPE is novel, similar research has shown promising results in understanding the molecular basis of age-related diseases.
Where this research is happening
JOHNSON CITY, UNITED STATES
- EAST TENNESSEE STATE UNIVERSITY — JOHNSON CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLEINMAN, MARK E — EAST TENNESSEE STATE UNIVERSITY
- Study coordinator: KLEINMAN, MARK E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder