A new method to boost the body's immune response against infections
Glucan glycomimetics: A new approach to stimulating innate immune training
This study is looking at how we can help your immune system remember and fight infections better by using a natural substance from fungi called β-glucans, with the hope of creating new treatments that offer longer-lasting protection against illnesses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Tennessee State University NIH-funded |
| Lab location | 1 site (Johnson City, United States) |
| Project ID | NIH-11120880 on NIH RePORTER |
What this research studies
This research explores how the innate immune system can be trained to respond more effectively to infections. It focuses on using β-glucans, which are components of fungal cell walls, to enhance the immune system's ability to remember and fight off pathogens. By developing drugs that harness this 'trained immunity', the goal is to provide broader and longer-lasting protection against various infections. The research aims to overcome challenges associated with the natural extraction of β-glucans, ensuring consistent and effective immune training.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and older adults who may have weakened immune systems.
Not a fit: Patients with strong, healthy immune systems may not see significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the body's ability to resist infections.
How similar studies have performed: Previous studies have shown that β-glucans can effectively induce trained immunity, suggesting a promising avenue for this research.
Where this research is happening
Johnson City, United States
- East Tennessee State University — Johnson City, United States (Active)
Researchers
- Principal investigator: Williams, David L. — East Tennessee State University
- Study coordinator: Williams, David L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.